Biology:Mannan-binding lectin-associated serine protease-2
From HandWiki
| Mannan-binding lectin-associated serine protease-2 | |||||||||
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| Identifiers | |||||||||
| EC number | 3.4.21.104 | ||||||||
| CAS number | 214915-16-9 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
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Mannan-binding lectin-associated serine protease-2 (EC 3.4.21.104, MASP-2, MASP2, MBP-associated serine protease-2, mannose-binding lectin-associated serine protease-2, p100, mannan-binding lectin-associated serine peptidase 2) is an enzyme.[1][2][3][4][5][6][7] This enzyme catalyses the following chemical reaction
- Selective cleavage after Arg223 in complement component C2 (-Ser-Leu-Gly-Arg-Lys-Ile-Gln-Ile) and after Arg76 in complement component C4 (-Gly-Leu-Gln-Arg-Ala-Leu-Glu-Ile)
This mannan-binding lectin (MBL) recognizes patterns of neutral carbohydrates, such as mannose and N-acetylglucosamine.
References
- ↑ "Activation of the classical complement pathway by mannose-binding protein in association with a novel C1s-like serine protease". The Journal of Experimental Medicine 176 (6): 1497–502. December 1992. doi:10.1084/jem.176.6.1497. PMID 1460414.
- ↑ "A second serine protease associated with mannan-binding lectin that activates complement". Nature 386 (6624): 506–10. April 1997. doi:10.1038/386506a0. PMID 9087411.
- ↑ "Substrate specificities of recombinant mannan-binding lectin-associated serine proteases-1 and -2". The Journal of Biological Chemistry 276 (44): 40880–7. November 2001. doi:10.1074/jbc.M105934200. PMID 11527969.
- ↑ "Natural substrates and inhibitors of mannan-binding lectin-associated serine protease-1 and -2: a study on recombinant catalytic fragments". Journal of Immunology 170 (3): 1374–82. February 2003. doi:10.4049/jimmunol.170.3.1374. PMID 12538697.
- ↑ "The structure of MBL-associated serine protease-2 reveals that identical substrate specificities of C1s and MASP-2 are realized through different sets of enzyme-substrate interactions". Journal of Molecular Biology 342 (5): 1533–46. October 2004. doi:10.1016/j.jmb.2004.07.014. PMID 15364579.
- ↑ "Two mechanisms for mannose-binding protein modulation of the activity of its associated serine proteases". The Journal of Biological Chemistry 279 (25): 26058–65. June 2004. doi:10.1074/jbc.M401318200. PMID 15060079.
- ↑ "The two major oligomeric forms of human mannan-binding lectin: chemical characterization, carbohydrate-binding properties, and interaction with MBL-associated serine proteases". Journal of Immunology 174 (5): 2870–7. March 2005. doi:10.4049/jimmunol.174.5.2870. PMID 15728497.
External links
- Mannan-binding+lectin-associated+serine+protease-2 at the US National Library of Medicine Medical Subject Headings (MeSH)
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