Biology:1,2-α-L-fucosidase
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Short description: Class of enzymes
| 1,2-α-L-Fucosidase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 3.2.1.63 | ||||||||
| CAS number | 37288-45-2 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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The enzyme 1,2-α-L-fucosidase (EC 3.2.1.63) catalyzes the following chemical reaction:
- methyl-2-α-L-fucopyranosyl-β-D-galactoside + H2O [math]\displaystyle{ \rightleftharpoons }[/math] L-fucose + methyl β-D-galactoside
It belongs to the family of hydrolases, specifically those glycosidases that hydrolyse O- and S-glycosyl compounds. The systematic name is 2-α-L-fucopyranosyl-β-D-galactoside fucohydrolase. Other names in common use include almond emulsin fucosidase, and α-(1→2)-L-fucosidase.
Structural studies
As of late 2007, 4 structures have been solved for this class of enzymes, with PDB accession codes 2EAB, 2EAC, 2EAD, and 2EAE.
References
- Bahl OP (1970). "Glycosidases of Aspergillus niger. II. Purification and general properties of 1,2-α-L-fucosidase". J. Biol. Chem. 245 (2): 299–304. PMID 5460888.
- "α-L-Fucosidases from almond emulsin: characterization of the two enzymes with different specificities". Arch. Biochem. Biophys. 181 (1): 353–8. 1977. doi:10.1016/0003-9861(77)90514-8. PMID 18111.
- "Glycosidases of molluscs. Purification and properties of α-L-fucosidase from Chamelea gallina L". Eur. J. Biochem. 66 (2): 379–87. 1976. doi:10.1111/j.1432-1033.1976.tb10527.x. PMID 7458.
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