Biology:Alpha-N-acetylglucosaminidase
From HandWiki
Short description: Class of enzymes
| α-N-acetylglucosaminidase | |
|---|---|
 | |
| Identifiers | |
| Symbol | NAGLU |
| NCBI gene | 4669 |
| HGNC | 7632 |
| OMIM | 609701 |
| RefSeq | NM_000263 |
| UniProt | P54802 |
| Other data | |
| EC number | 3.2.1.50 |
| Locus | Chr. 17 q11-q21 |
α-N-acetylglucosaminidase (EC 3.2.1.50, α-acetylglucosaminidase, N-acetyl-α-D-glucosaminidase, N-acetyl-α-glucosaminidase, α-D-2-acetamido-2-deoxyglucosidase) is a protein associated with Sanfilippo syndrome. It is an enzyme with systematic name α-N-acetyl-D-glucosaminide N-acetylglucosaminohydrolase.[2][3][4][5] This enzyme catalyses the following chemical reaction
- Hydrolysis of terminal non-reducing N-acetyl-D-glucosamine residues in N-acetyl-α-D-glucosaminides
This enzyme hydrolyses UDP-N-acetylglucosamine.
References
- ↑ Birrane, Gabriel; Dassier, Anne-Laure; Romashko, Alla; Lundberg, Dianna; Holmes, Kevin; Cottle, Thomas; Norton, Angela W.; Zhang, Bohong et al. (2019). "Structural characterization of the α-N-acetylglucosaminidase, a key enzyme in the pathogenesis of Sanfilippo syndrome B" (in en). Journal of Structural Biology 205 (3): 65–71. doi:10.1016/j.jsb.2019.02.005. https://linkinghub.elsevier.com/retrieve/pii/S1047847719300280.
- ↑ "Human alpha-N-acetylglucosaminidase. 1. Purification and properties". European Journal of Biochemistry 80 (2): 523–533. November 1977. doi:10.1111/j.1432-1033.1977.tb11908.x. PMID 411658.
- ↑ "Human alpha-n-acetylglucosaminidase. 2. Activity towards natural substrates and multiple recognition forms". European Journal of Biochemistry 80 (2): 535–542. November 1977. doi:10.1111/j.1432-1033.1977.tb11909.x. PMID 923593.
- ↑ "Mammalian alpha-acetylglucosaminidase. Enzymic properties, tissue distribution, and intracellular localization". Biochemistry 6 (1): 207–214. January 1967. doi:10.1021/bi00853a033. PMID 4291567.
- ↑ "Separation of N-acetyl-alpha-glucosaminidase and N-acetyl-alpha-galactosaminidase from ox spleen. Cleavage of the O-glycosidic linkage between carbohydrate and polypeptide in ovine and bovine submaxillary glycoprotein by N-acetyl-alpha-galactosaminidase". European Journal of Biochemistry 10 (3): 445–449. October 1969. doi:10.1111/j.1432-1033.1969.tb00709.x. PMID 5348072.
External links
- alpha-N-acetyl-D-glucosaminidase at the US National Library of Medicine Medical Subject Headings (MeSH)
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