Biology:GBA3

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

Cytosolic beta-glucosidase, also known as cytosolic beta-glucosidase-like protein 1, is a beta-glucosidase (EC 3.2.1.21) enzyme that in humans is encoded by the GBA3 gene.

Function

Cytosolic beta-glucosidase is a predominantly liver enzyme that efficiently hydrolyzes beta-D-glucoside and beta-D-galactoside, but not any known physiologic beta-glycoside, suggesting that it may be involved in detoxification of plant glycosides. GBA3 also has significant neutral glycosylceramidase activity (EC 3.2.1.62), suggesting that it may be involved in a non-lysosomal catabolic pathway of glucosylceramide metabolism.

See also

• Closely related enzymes
  • GBA: acid β-glucosidase, EC 3.2.1.45
  • GBA2: acid β-glucosidase (bile acid), also EC 3.2.1.45

Further reading

• "Influence of N-linked glycans in V4-V5 region of human immunodeficiency virus type 1 glycoprotein gp160 on induction of a virus-neutralizing humoral response". J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. 12 (3): 213–20. July 1996. doi:10.1097/00042560-199607000-00001. PMID 8673525. 
• "Mutations in the gene encoding cytosolic beta-glucosidase in Gaucher disease.". J. Lab. Clin. Med. 144 (2): 65–8. 2004. doi:10.1016/j.lab.2004.03.013. PMID 15322500. 
• "Molecular cloning and expression of a novel klotho-related protein.". J. Mol. Med. 78 (7): 389–94. 2000. doi:10.1007/s001090000131. PMID 11043382. 
• "Hyperglycosylated mutants of human immunodeficiency virus (HIV) type 1 monomeric gp120 as novel antigens for HIV vaccine design.". J. Virol. 77 (10): 5889–901. 2003. doi:10.1128/JVI.77.10.5889-5901.2003. PMID 12719582. 
• "The crystal structure of human cytosolic beta-glucosidase unravels the substrate aglycone specificity of a family 1 glycoside hydrolase.". J. Mol. Biol. 370 (5): 964–75. 2007. doi:10.1016/j.jmb.2007.05.034. PMID 17555766. 
• "Crystal structure of the covalent intermediate of human cytosolic beta-glucosidase.". Biochem. Biophys. Res. Commun. 374 (3): 549–52. 2008. doi:10.1016/j.bbrc.2008.07.089. PMID 18662675. 
• "Substrate (aglycone) specificity of human cytosolic beta-glucosidase.". Biochem. J. 373 (Pt 1): 41–8. 2003. doi:10.1042/BJ20021876. PMID 12667141. 
• "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1–2): 149–56. 1997. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149. 
• "N-Glycans in the gp120 V1/V2 domain of the HIV-1 strain NL4-3 are indispensable for viral infectivity and resistance against antibody neutralization.". Med. Microbiol. Immunol. 195 (3): 165–72. 2006. doi:10.1007/s00430-006-0016-z. PMID 16547752. 
• "Effect of various glycosidase treatments on the resistance of the HIV-1 envelope to degradation.". FEBS Lett. 406 (1–2): 191–5. 1997. doi:10.1016/S0014-5793(97)00273-1. PMID 9109416. 
• "The cytosolic beta-glucosidase GBA3 does not influence type 1 Gaucher disease manifestation.". Blood Cells Mol. Dis. 46 (1): 19–26. 2010. doi:10.1016/j.bcmd.2010.07.009. PMID 20728381. 
• "Functional expression of human liver cytosolic beta-glucosidase in Pichia pastoris. Insights into its role in the metabolism of dietary glucosides.". Eur. J. Biochem. 269 (1): 249–58. 2002. doi:10.1046/j.0014-2956.2001.02641.x. PMID 11784319. 
• "AIDS and glycosylation.". Glycobiology 1 (1): 17–23. 1990. doi:10.1093/glycob/1.1.17. PMID 2136376. 
• "Deglycosylation by small intestinal epithelial cell beta-glucosidases is a critical step in the absorption and metabolism of dietary flavonoid glycosides in humans.". Eur J Nutr 42 (1): 29–42. 2003. doi:10.1007/s00394-003-0397-3. PMID 12594539. 
• "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334. 
• "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2002. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M. 
• "Folding of the human immunodeficiency virus type 1 envelope glycoprotein in the endoplasmic reticulum.". Biochimie 83 (8): 783–90. 2001. doi:10.1016/S0300-9084(01)01314-1. PMID 11530211. 
• "Glycosylation inhibitors and neuraminidase enhance human immunodeficiency virus type 1 binding and neutralization by mannose-binding lectin.". J. Gen. Virol. 84 (Pt 2): 353–60. 2003. doi:10.1099/vir.0.18734-0. PMID 12560567. 

External links

• PDBe-KB provides an overview of all the structure information available in the PDB for Human Cytosolic beta-glucosidase