Biology:A4GNT

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Alpha-1,4-N-acetylglucosaminyl­transferase is an enzyme that in humans is encoded by the A4GNT gene.[1] This enzyme is part of the production of type III mucin, which is found in the stomach, duodenum, and pancreatic ducts.[2]

Enzyme activity

This enzyme functions as an acetylglucosaminyl­transferase, which means it moves an acetylglucosamine (GlcNAc) from one molecule to another. In this case it moves the GlcNAc from a UDP-N-acetyl-alpha-D-glucosamine donor to a galactose residue on an O-glycans.[2] It catalyzes the following reaction:[2]

a beta-D-galactoside + UDP-N-acetyl-alpha-D-glucosamine → an N-acetyl-alpha-D-glucosaminyl-(1->4)-beta-D-galactosyl derivative + UDP + H+

It can also apply to beta-(1->3)-linked residues.[2]

References

  1. ↑ "A4GNT alpha-1,4-N-acetylglucosaminyltransferase". NCBI. https://www.ncbi.nlm.nih.gov/gene?cmd=retrieve&dopt=default&rn=1&list_uids=51146. 
  2. ↑ 2.0 2.1 2.2 2.3 "Alpha-1,4-N-acetylglucosaminyltransferase". UniProt consortium. https://www.uniprot.org/uniprotkb/Q9UNA3/entry. 




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