Biology:APOBEC3D
 Generic protein structure example |
Probable DNA dC->dU-editing enzyme APOBEC-3D is a protein that in humans is encoded by the APOBEC3D gene.[1][2]
This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1 and inhibit retroviruses, such as HIV, by deaminating cytosine residues in nascent retroviral cDNA.[2]
Function
APOBEC3D is one of the human APOBEC3 enzymes involved in restriction of HIV-1.[3][4] HIV-1 Vif counteracts APOBEC3D by recruiting ubiquitin-ligase machinery that leads to its polyubiquitination and proteasomal degradation in virus-producing cells.[3][4]
References
- ↑ "An anthropoid-specific locus of orphan C to U RNA-editing enzymes on chromosome 22". Genomics 79 (3): 285–296. February 2002. doi:10.1006/geno.2002.6718. PMID 11863358.
- ↑ 2.0 2.1 "Entrez Gene: APOBEC3D apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3D (putative)". https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=140564.
- ↑ 3.0 3.1 "Structural Insights into APOBEC3-Mediated Lentiviral Restriction". Viruses 12 (6): 587. May 2020. doi:10.3390/v12060587. PMID 32471198.
- ↑ 4.0 4.1 "Suppression of APOBEC3-mediated restriction of HIV-1 by Vif". Frontiers in Microbiology 5. 2014. doi:10.3389/fmicb.2014.00450. PMID 25206352.
External links
- Human APOBEC3D genome location and APOBEC3D gene details page in the UCSC Genome Browser.
Further reading
- "Messenger RNA editing in mammals: new members of the APOBEC family seeking roles in the family business". Trends in Genetics 19 (4): 207–216. 2003. doi:10.1016/S0168-9525(03)00054-4. PMID 12683974.
- "Retroviral restriction by APOBEC proteins". Nature Reviews. Immunology 4 (11): 868–877. 2004. doi:10.1038/nri1489. PMID 15516966.
- "The DNA sequence of human chromosome 22". Nature 402 (6761): 489–495. December 1999. doi:10.1038/990031. PMID 10591208. Bibcode: 1999Natur.402..489D.
- "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proceedings of the National Academy of Sciences of the United States of America 97 (7): 3491–3496. March 2000. doi:10.1073/pnas.97.7.3491. PMID 10737800. Bibcode: 2000PNAS...97.3491D.
- "Species-specific exclusion of APOBEC3G from HIV-1 virions by Vif". Cell 114 (1): 21–31. July 2003. doi:10.1016/S0092-8674(03)00515-4. PMID 12859895.
- "Ancient adaptive evolution of the primate antiviral DNA-editing enzyme APOBEC3G". PLoS Biology 2 (9): E275. 2006. doi:10.1371/journal.pbio.0020275. PMID 15269786.
- "A genome annotation-driven approach to cloning the human ORFeome". Genome Biology 5 (10). 2004. doi:10.1186/gb-2004-5-10-r84. PMID 15461802.
- "Identification of APOBEC3DE as another antiretroviral factor from the human APOBEC family". Journal of Virology 80 (21): 10522–10533. 2006. doi:10.1128/JVI.01123-06. PMID 16920826.
- "All APOBEC3 family proteins differentially inhibit LINE-1 retrotransposition". Nucleic Acids Research 35 (9): 2955–2964. 2007. doi:10.1093/nar/gkm181. PMID 17439959.
 |  |
