Biology:APOBEC3F
From HandWiki
Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
DNA dC->dU-editing enzyme APOBEC-3F is a protein that in humans is encoded by the APOBEC3F gene.[1][2][3]
This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. It is thought that the proteins may be RNA editing enzymes and have roles in growth or cell cycle control. Alternatively spliced transcript variants encoding different isoforms have been identified.[3]
References
- ↑ "An anthropoid-specific locus of orphan C to U RNA-editing enzymes on chromosome 22". Genomics 79 (3): 285–96. Feb 2002. doi:10.1006/geno.2002.6718. PMID 11863358.
- ↑ "APOBEC3F can inhibit the accumulation of HIV-1 reverse transcription products in the absence of hypermutation. Comparisons with APOBEC3G". J Biol Chem 282 (4): 2587–95. Jan 2007. doi:10.1074/jbc.M607298200. PMID 17121840.
- ↑ 3.0 3.1 "Entrez Gene: APOBEC3F apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3F". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=200316.
Human APOBEC3F is another host factor that blocks human immunodeficiency virus type 1 replication. Zheng YH, Irwin D, Kurosu T, Tokunaga K, Sata T, Peterlin BM. J Virol. 2004 Jun;78(11):6073-6. doi: 10.1128/JVI.78.11.6073-6076.2004.
External links
- Human APOBEC3F genome location and APOBEC3F gene details page in the UCSC Genome Browser.
Further reading
- "Messenger RNA editing in mammals: new members of the APOBEC family seeking roles in the family business.". Trends Genet. 19 (4): 207–16. 2003. doi:10.1016/S0168-9525(03)00054-4. PMID 12683974.
- "APOBEC deaminases as cellular antiviral factors: a novel natural host defense mechanism.". Med. Sci. Monit. 12 (5): RA92–8. 2006. PMID 16641889.
- "Analysis of differential gene expression by display of 3' end restriction fragments of cDNAs.". Proc. Natl. Acad. Sci. U.S.A. 93 (2): 659–63. 1996. doi:10.1073/pnas.93.2.659. PMID 8570611. Bibcode: 1996PNAS...93..659P.
- "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. 1997. doi:10.1101/gr.6.9.791. PMID 8889548.
- "The DNA sequence of human chromosome 22.". Nature 402 (6761): 489–95. 1999. doi:10.1038/990031. PMID 10591208. Bibcode: 1999Natur.402..489D.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Human APOBEC3F is another host factor that blocks human immunodeficiency virus type 1 replication.". J. Virol. 78 (11): 6073–6. 2004. doi:10.1128/JVI.78.11.6073-6076.2004. PMID 15141007.
- "A second human antiretroviral factor, APOBEC3F, is suppressed by the HIV-1 and HIV-2 Vif proteins.". EMBO J. 23 (12): 2451–8. 2004. doi:10.1038/sj.emboj.7600246. PMID 15152192.
- "APOBEC3F properties and hypermutation preferences indicate activity against HIV-1 in vivo.". Curr. Biol. 14 (15): 1385–91. 2004. doi:10.1016/j.cub.2004.06.050. PMID 15296757.
- "A genome annotation-driven approach to cloning the human ORFeome.". Genome Biol. 5 (10): R84. 2005. doi:10.1186/gb-2004-5-10-r84. PMID 15461802.
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "The retroviral hypermutation specificity of APOBEC3F and APOBEC3G is governed by the C-terminal DNA cytosine deaminase domain.". J. Biol. Chem. 280 (12): 10920–4. 2005. doi:10.1074/jbc.M500382200. PMID 15647250.
- "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. 2006. doi:10.1101/gr.4039406. PMID 16344560.
- "Comparative analysis of the antiretroviral activity of APOBEC3G and APOBEC3F from primates.". Virology 349 (1): 31–40. 2006. doi:10.1016/j.virol.2005.12.035. PMID 16460778.
- "Differential requirement for conserved tryptophans in human immunodeficiency virus type 1 Vif for the selective suppression of APOBEC3G and APOBEC3F.". J. Virol. 80 (6): 3112–5. 2006. doi:10.1128/JVI.80.6.3112-3115.2006. PMID 16501124.
- "APOBEC3B and APOBEC3F inhibit L1 retrotransposition by a DNA deamination-independent mechanism.". J. Biol. Chem. 281 (25): 16837–41. 2006. doi:10.1074/jbc.M602367200. PMID 16648136.
- "Human retroviral host restriction factors APOBEC3G and APOBEC3F localize to mRNA processing bodies.". PLOS Pathog. 2 (5): e41. 2006. doi:10.1371/journal.ppat.0020041. PMID 16699599.
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