Biology:Atrolysin C
From HandWiki
| Atrolysin C | |||||||||
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| Identifiers | |||||||||
| EC number | 3.4.24.42 | ||||||||
| CAS number | 158886-17-0 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
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Atrolysin C (EC 3.4.24.42, Crotalus atrox metalloendopeptidase c, hemorrhagic toxin c and d) is an enzyme.[1][2][3][4][5][6] This enzyme catalyses the following chemical reaction
- Cleavage of His5-Leu, His10-Leu, Ala14-Leu, Tyr16-Leu and Gly23-Phe bonds in B chain of insulin. With small molecule substrates prefers hydrophobic residue at P2' and small residue such as Ala, Gly at P1
This endopeptidase is present in the venom of the western diamondback rattlesnake (Crotalus atrox).
References
- ↑ "Hemorrhagic toxins from Western diamondback rattlesnake (Crotalus atrox) venom: isolation and characterization of five toxins and the role of zinc in hemorrhagic toxin e". Biochemistry 17 (16): 3395–404. August 1978. doi:10.1021/bi00609a033. PMID 210790.
- ↑ "Substrate specificities and inhibition of two hemorrhagic zinc proteases Ht-c and Ht-d from Crotalus atrox venom". European Journal of Biochemistry 156 (1): 65–72. April 1986. doi:10.1111/j.1432-1033.1986.tb09549.x. PMID 3514216.
- ↑ "Characterization of two hemorrhagic zinc proteinases, toxin c and toxin d, from western diamondback rattlesnake (Crotalus atrox) venom". Biochimica et Biophysica Acta (BBA) - Protein Structure and Molecular Enzymology 911 (3): 356–63. February 1987. doi:10.1016/0167-4838(87)90077-x. PMID 3101740.
- ↑ "Biochemical characterization of hemorrhagic toxins with fibrinogenase activity isolated from Crotalus ruber ruber venom". Archives of Biochemistry and Biophysics 253 (1): 108–21. February 1987. doi:10.1016/0003-9861(87)90643-6. PMID 2949699.
- ↑ "Amino acid sequence of a Crotalus atrox venom metalloproteinase which cleaves type IV collagen and gelatin". The Journal of Biological Chemistry 264 (20): 11575–83. July 1989. PMID 2745407.
- ↑ "Primary structure of a hemorrhagic metalloproteinase, HT-2, isolated from the venom of Crotalus ruber ruber". Journal of Biochemistry 108 (5): 711–9. November 1990. doi:10.1093/oxfordjournals.jbchem.a123270. PMID 2081731.
External links
- Atrolysin+C at the US National Library of Medicine Medical Subject Headings (MeSH)
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