Biology:C5a peptidase
From HandWiki
| C5a peptidase | |||||||||
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| Identifiers | |||||||||
| EC number | 3.4.21.110 | ||||||||
| CAS number | 100179-39-3 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
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C5a peptidase (EC 3.4.21.110, streptococcal C5a peptidase, ScpA, ScpB, SCPA) is an enzyme.[1][2][3][4][5][6] The primary cleavage site is at His67-Lys68 in human C5a with a minor secondary cleavage site at Ala58-Ser59.
This enzyme is a surface-associated subtilisin-like serine peptidase with very specific substrate preference.
References
- ↑ "Mechanism of action of the group A streptococcal C5a inactivator". Proceedings of the National Academy of Sciences of the United States of America 82 (23): 8144–8. December 1985. doi:10.1073/pnas.82.23.8144. PMID 3906656.
- ↑ "Group B streptococci inactivate complement component C5a by enzymic cleavage at the C-terminus". The Biochemical Journal 273 ( Pt 3) (3): 635–40. February 1991. doi:10.1042/bj2730635. PMID 1996961.
- ↑ "Streptococcal C5a peptidase is a highly specific endopeptidase". Infection and Immunity 60 (12): 5219–23. December 1992. doi:10.1128/iai.60.12.5219-5223.1992. PMID 1452354.
- ↑ "Processing, stability, and kinetic parameters of C5a peptidase from Streptococcus pyogenes". European Journal of Biochemistry 269 (19): 4839–51. October 2002. doi:10.1046/j.1432-1033.2002.03183.x. PMID 12354115.
- ↑ "Characterization of the streptococcal C5a peptidase using a C5a-green fluorescent protein fusion protein substrate". Journal of Bacteriology 182 (11): 3254–8. June 2000. doi:10.1128/jb.182.11.3254-3258.2000. PMID 10809707.
- ↑ "Multifunctional glyceraldehyde-3-phosphate dehydrogenase of Streptococcus pyogenes is essential for evasion from neutrophils". The Journal of Biological Chemistry 281 (20): 14215–23. May 2006. doi:10.1074/jbc.M513408200. PMID 16565520.
External links
- C5a+peptidase at the US National Library of Medicine Medical Subject Headings (MeSH)
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