Biology:dCTP deaminase (dUMP-forming)
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DCTP deaminase (dUMP-forming) | |||||||||
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Identifiers | |||||||||
EC number | 3.5.4.30 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
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In enzymology, a dCTP deaminase (dUMP-forming) (EC 3.5.4.30) is an enzyme that catalyzes the chemical reaction
- dCTP + 2 H2O [math]\displaystyle{ \rightleftharpoons }[/math] dUMP + diphosphate + NH3
Thus, the two substrates of this enzyme are dCTP and H2O, whereas its 3 products are dUMP, diphosphate, and NH3.
This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in cyclic amidines. The systematic name of this enzyme class is dCTP aminohydrolase (dUMP-forming). This enzyme participates in pyrimidine metabolism.
Structural studies
As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes 2HXB, 2HXD, and 2HXE.
References
- "The Methanococcus jannaschii dCTP deaminase is a bifunctional deaminase and diphosphatase". J. Biol. Chem. 278 (13): 11100–6. 2003. doi:10.1074/jbc.M212460200. PMID 12538648.
![]() | Original source: https://en.wikipedia.org/wiki/DCTP deaminase (dUMP-forming).
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