Biology:Endothelin-converting enzyme 1
From HandWiki
| Endothelin-converting enzyme 1 | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 3.4.24.71 | ||||||||
| CAS number | 138238-81-0 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Endothelin-converting enzyme 1 (EC 3.4.24.71, endothelin-converting enzyme, ECE-1) is an enzyme.[1][2][3] This enzyme catalyses the following chemical reaction
- Hydrolysis of the -Trp21-Val- bond in big endothelin to form endothelin 1
This metalloendopeptidase belongs to the peptidase family M13.
References
- ↑ "Purification and characterization of endothelin-converting enzyme from rat lung". The Journal of Biological Chemistry 268 (28): 21394–8. October 1993. doi:10.1016/S0021-9258(19)36936-4. PMID 8407980.
- ↑ "Cloning and functional expression of endothelin-converting enzyme from rat endothelial cells". The Journal of Biological Chemistry 269 (28): 18275–8. July 1994. doi:10.1016/S0021-9258(17)32298-6. PMID 8034569.
- ↑ "ECE-1: a membrane-bound metalloprotease that catalyzes the proteolytic activation of big endothelin-1". Cell 78 (3): 473–85. August 1994. doi:10.1016/0092-8674(94)90425-1. PMID 8062389.
External links
- Endothelin-converting+enzyme+1 at the US National Library of Medicine Medical Subject Headings (MeSH)
 |  |
