Biology:FGGY carbohydrate kinase family
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Short description: Family of enzymes
| FGGY family of carbohydrate kinases, N-terminal domain | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 enterococcus casseliflavus glycerol kinase complexed with glycerol | |||||||||
| Identifiers | |||||||||
| Symbol | FGGY_N | ||||||||
| Pfam | PF00370 | ||||||||
| Pfam clan | CL0108 | ||||||||
| InterPro | IPR018484 | ||||||||
| PROSITE | PDOC00408 | ||||||||
| SCOP2 | 1gla / SCOPe / SUPFAM | ||||||||
| CDD | cd00366 | ||||||||
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| FGGY family of carbohydrate kinases, C-terminal domain | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 escherichia coli glycerol kinase mutant with bound atp analog showing substantial domain motion | |||||||||
| Identifiers | |||||||||
| Symbol | FGGY_C | ||||||||
| Pfam | PF02782 | ||||||||
| Pfam clan | CL0108 | ||||||||
| InterPro | IPR018485 | ||||||||
| PROSITE | PDOC00408 | ||||||||
| SCOP2 | 1gla / SCOPe / SUPFAM | ||||||||
| CDD | cd00366 | ||||||||
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In molecular biology the FGGY carbohydrate kinase family is a family of evolutionarily related carbohydrate kinase enzymes. These enzymes include L-fuculokinase EC 2.7.1.51 (gene fucK); gluconokinase EC 2.7.1.12 (gene gntK); glycerol kinase EC 2.7.1.30 (gene glpK); xylulokinase EC 2.7.1.17 (gene xylB); D-ribulose kinase EC 2.7.1.47 (gene FGGY/YDR109c);[1] and L-xylulose kinase EC 2.7.1.53 (gene lyxK). These enzymes are proteins of from 480 to 520 amino acid residues.
These enzymes consist of two domains. The N-terminal and C-terminal domains both adopt a ribonuclease H-like fold and are structurally related to each other.[1][2][3]
References
- ↑ 1.0 1.1 "Molecular Identification of D-Ribulokinase in Budding Yeast and Mammals". J. Biol. Chem. 292 (3): 1005–1028. 2016. doi:10.1074/jbc.M116.760744. PMID 27909055.
- ↑ "Structure of the regulatory complex of Escherichia coli IIIGlc with glycerol kinase". Science 259 (5095): 673–7. January 1993. doi:10.1126/science.8430315. PMID 8430315. Bibcode: 1993Sci...259..673H.
- ↑ "Crystal structure of a complex of Escherichia coli glycerol kinase and an allosteric effector fructose 1,6-bisphosphate". Biochemistry 37 (47): 16565–72. November 1998. doi:10.1021/bi981616s. PMID 9843423.
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