Biology:FUT1

Short description: Protein and coding gene in humans

Generic protein structure example

Galactoside 2-alpha-L-fucosyltransferase 1 is an enzyme that in humans is encoded by the FUT1 gene.

The enzyme is involved in the synthesis of the H antigen.

Further reading

• "The human chromosome 19 linkage group FUT1 (H), FUT2 (SE), LE, LU, PEPD, C3, APOC2, D19S7 and D19S9". Annals of Human Genetics 55 (Pt 3): 225–33. July 1991. doi:10.1111/j.1469-1809.1991.tb00417.x. PMID 1763885. 
• "Molecular cloning, sequence, and expression of a human GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase cDNA that can form the H blood group antigen". Proceedings of the National Academy of Sciences of the United States of America 87 (17): 6674–8. September 1990. doi:10.1073/pnas.87.17.6674. PMID 2118655. Bibcode: 1990PNAS...87.6674L. 
• "Relative positions of two clusters of human alpha-L-fucosyltransferases in 19q (FUT1-FUT2) and 19p (FUT6-FUT3-FUT5) within the microsatellite genetic map of chromosome 19". Cytogenetics and Cell Genetics 71 (2): 158–62. 1995. doi:10.1159/000134098. PMID 7656588. 
• "Chaperone function of a Grp 94-related protein for folding and transport of the pancreatic bile salt-dependent lipase". The Journal of Biological Chemistry 270 (22): 13524–33. June 1995. doi:10.1074/jbc.270.22.13524. PMID 7768954. 
• "Molecular basis for H blood group deficiency in Bombay (Oh) and para-Bombay individuals". Proceedings of the National Academy of Sciences of the United States of America 91 (13): 5843–7. June 1994. doi:10.1073/pnas.91.13.5843. PMID 7912436. Bibcode: 1994PNAS...91.5843K. 
• "Structure and expression of H-type GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase gene (FUT1). Two transcription start sites and alternative splicing generate several forms of FUT1 mRNA". The Journal of Biological Chemistry 272 (11): 7501–5. March 1997. doi:10.1074/jbc.272.11.7501. PMID 9054453. 
• "Polymorphism of the h allele and the population frequency of sporadic nonfunctional alleles". Transfusion 37 (3): 284–90. March 1997. doi:10.1046/j.1537-2995.1997.37397240210.x. PMID 9122901. 
• "Wide variety of point mutations in the H gene of Bombay and para-Bombay individuals that inactivate H enzyme". Blood 90 (2): 839–49. July 1997. doi:10.1182/blood.V90.2.839. PMID 9226185. 
• "Missense mutation of FUT1 and deletion of FUT2 are responsible for Indian Bombay phenotype of ABO blood group system". Biochemical and Biophysical Research Communications 238 (1): 21–5. September 1997. doi:10.1006/bbrc.1997.7232. PMID 9299444. Bibcode: 1997BBRC..238...21K. 
• "Changing transcription start sites in H-type alpha(1,2)fucosyltransferase gene (FUT1) during differentiation of the human erythroid lineage". European Journal of Biochemistry 256 (2): 379–87. September 1998. doi:10.1046/j.1432-1327.1998.2560379.x. PMID 9760178. 
• "Composition of Drosophila melanogaster proteome involved in fucosylated glycan metabolism". The Journal of Biological Chemistry 277 (5): 3168–75. February 2002. doi:10.1074/jbc.M107927200. PMID 11698403. 
• "Molecular genetic analysis of para-Bombay phenotypes in Chinese: a novel non-functional FUT1 allele is identified". Vox Sanguinis 83 (3): 258–62. October 2002. doi:10.1046/j.1423-0410.2002.00184.x. PMID 12366770. 
• "The expression of human FUT1 in HT-29/M3 colon cancer cells instructs the glycosylation of MUC1 and MUC5AC apomucins". Glycoconjugate Journal 19 (1): 13–21. January 2002. doi:10.1023/A:1022576712961. PMID 12652076. 
• "Protein O-fucosyltransferase 1 is an essential component of Notch signaling pathways". Proceedings of the National Academy of Sciences of the United States of America 100 (9): 5234–9. April 2003. doi:10.1073/pnas.0831126100. PMID 12697902. Bibcode: 2003PNAS..100.5234S. 
• "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nature Biotechnology 22 (6): 707–16. June 2004. doi:10.1038/nbt971. PMID 15146197. 
• "[Analysis on FUT1 and FUT2 gene of 10 para-Bombay individuals in China]". Zhonghua Yi Xue Yi Chuan Xue Za Zhi = Zhonghua Yixue Yichuanxue Zazhi = Chinese Journal of Medical Genetics 21 (5): 417–21. October 2004. PMID 15476160. 
• "Molecular basis for para-Bombay phenotypes in Chinese persons, including a novel nonfunctional FUT1 allele". Transfusion 45 (5): 725–30. May 2005. doi:10.1111/j.1537-2995.2005.04305.x. PMID 15847661. 
• "Changes in the invasive and metastatic capacities of HT-29/M3 cells induced by the expression of fucosyltransferase 1". Cancer Science 98 (7): 1000–5. July 2007. doi:10.1111/j.1349-7006.2007.00484.x. PMID 17459061.