Biology:Fragilysin
From HandWiki
Fragilysin (EC 3.4.24.74, Bacteroides fragilis (entero)toxin) is an enzyme.[1][2][3][4][5] This enzyme catalyses the following chemical reaction
- Broad proteolytic specificity, bonds hydrolysed including -Gly-Leu-, -Met-Leu-, -Phe-Leu-, -Cys-Leu-, Leu-Gly
It is thought to be a cause of diarrhoea in animals and humans.
References
- ↑ "The enterotoxin of Bacteroides fragilis is a metalloprotease". Infection and Immunity 63 (1): 175–81. January 1995. PMID 7806355.
- ↑ "Proteolytic activity of the Bacteroides fragilis enterotoxin causes fluid secretion and intestinal damage in vivo". Infection and Immunity 63 (10): 3820–6. October 1995. PMID 7558286.
- ↑ "Bacteroides fragilis enterotoxin induces cytoskeletal changes and surface blebbing in HT-29 cells". Infection and Immunity 64 (1): 113–9. January 1996. PMID 8557328.
- ↑ "Human intestinal epithelial cells swell and demonstrate actin rearrangement in response to the metalloprotease toxin of Bacteroides fragilis". Infection and Immunity 64 (12): 5022–8. December 1996. PMID 8945541.
- ↑ "Cloning and characterization of the gene for the metalloprotease enterotoxin of Bacteroides fragilis". FEMS Microbiology Letters 146 (2): 279–84. January 1997. doi:10.1016/s0378-1097(96)00488-0. PMID 9011050.
External links
- Fragilysin at the US National Library of Medicine Medical Subject Headings (MeSH)
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