Biology:GUCY2F
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Short description: Protein-coding gene in humans
 Generic protein structure example |
Retinal guanylyl cyclase 2 also known as guanylate cyclase F (GUCY2F) is a protein that in humans is encoded by the GUCY2F gene.[1]
Function
The protein encoded by this gene is a guanylyl cyclase found predominantly in photoreceptors in the retina. The encoded protein is thought to be involved in resynthesis of cGMP after light activation of the visual signal transduction cascade, allowing a return to the dark state. This protein is a single-pass type I membrane protein.[1]
Clinical significance
Defects in this gene may be a cause of X-linked retinitis pigmentosa.[1]
References
Further reading
- "Genetic mutations associated with cigarette smoking in pancreatic cancer". Cancer Res. 69 (8): 3681–8. April 2009. doi:10.1158/0008-5472.CAN-09-0015. PMID 19351817.
- "Cloning and expression of a second photoreceptor-specific membrane retina guanylyl cyclase (RetGC), RetGC-2". Proc. Natl. Acad. Sci. U.S.A. 92 (12): 5535–9. June 1995. doi:10.1073/pnas.92.12.5535. PMID 7777544. Bibcode: 1995PNAS...92.5535L.
- "Chromosomal localization and genomic organization of genes encoding guanylyl cyclase receptors expressed in olfactory sensory neurons and retina". Genomics 31 (3): 367–72. February 1996. doi:10.1006/geno.1996.0060. PMID 8838319.
- "Two eye guanylyl cyclases are expressed in the same photoreceptor cells and form homomers in preference to heteromers". J. Biol. Chem. 272 (21): 13738–42. May 1997. doi:10.1074/jbc.272.21.13738. PMID 9153227.
- "Somatic mutations of GUCY2F, EPHA3, and NTRK3 in human cancers". Hum. Mutat. 27 (10): 1060–1. October 2006. doi:10.1002/humu.9452. PMID 16941478.
- "The kinase homology domain of retinal guanylyl cyclases 1 and 2 specifies the affinity and cooperativity of interaction with guanylyl cyclase activating protein-2". Biochemistry 37 (32): 11264–71. August 1998. doi:10.1021/bi9809674. PMID 9698373.
- "Expression level and activity profile of membrane bound guanylate cyclase type 2 in rod outer segments". J. Neurochem. 103 (4): 1439–46. November 2007. doi:10.1111/j.1471-4159.2007.04923.x. PMID 17868328.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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