Biology:HDAC11
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Histone deacetylase 11 is a 39kDa histone deacetylase enzyme that in humans is encoded by the HDAC11 gene on chromosome 3 in humans and chromosome 6 in mice.[1][2]
It is the only Class IV HDAC since it is not highly homologous with either Rpd3 or hda1 yeast enzymes and so does not fit into either Class I or Class II.[3] It is the smallest HDAC isoform and it was first described in 2002.
Function
Histone deacetylases, such as HDAC11, control DNA expression by modifying the core histone octamers that package DNA into dense chromatin structures and repress gene expression.[supplied by OMIM][2]
HDAC11 expression is normally found in brain and testis tissue, but upregulation of HDAC11 expression has also been seen in various cancer cells.
HDAC11 has been shown to be a negative regulator of IL-10 production in antigen presenting cells. It has also been shown that inhibition of HDAC11 results in increased expression of OX40L in Hodgkin lymphoma cells.
Interactions
HDAC11 has been shown to interact with HDAC6.[1]
See also
References
- ↑ 1.0 1.1 "Cloning and functional characterization of HDAC11, a novel member of the human histone deacetylase family". The Journal of Biological Chemistry 277 (28): 25748–55. Jul 2002. doi:10.1074/jbc.M111871200. PMID 11948178.
- ↑ 2.0 2.1 "Entrez Gene: HDAC11 histone deacetylase 11". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=79885.
- ↑ "The Rpd3/Hda1 family of lysine deacetylases: from bacteria and yeast to mice and men". Nature Reviews Molecular Cell Biology 9 (3): 206–18. Mar 2008. doi:10.1038/nrm2346. PMID 18292778.
Further reading
- "Class II histone deacetylases: versatile regulators". Trends in Genetics 19 (5): 286–93. May 2003. doi:10.1016/S0168-9525(03)00073-8. PMID 12711221.
- "DNA cloning using in vitro site-specific recombination". Genome Research 10 (11): 1788–95. Nov 2000. doi:10.1101/gr.143000. PMID 11076863.
- "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Reports 1 (3): 287–92. Sep 2000. doi:10.1093/embo-reports/kvd058. PMID 11256614.
- "From ORFeome to biology: a functional genomics pipeline". Genome Research 14 (10B): 2136–44. Oct 2004. doi:10.1101/gr.2576704. PMID 15489336.
- "Chromosomal organization and localization of the novel class IV human histone deacetylase 11 gene". International Journal of Molecular Medicine 16 (4): 589–98. Oct 2005. doi:10.3892/ijmm.16.4.589. PMID 16142391.
- "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. Oct 2005. doi:10.1038/nature04209. PMID 16189514. Bibcode: 2005Natur.437.1173R.
- "The LIFEdb database in 2006". Nucleic Acids Research 34 (Database issue): D415–8. Jan 2006. doi:10.1093/nar/gkj139. PMID 16381901.
- "Mutational analyses of WNT7A and HDAC11 as candidate tumour suppressor genes in sporadic malignant pancreatic endocrine tumours". Clinical Endocrinology 66 (1): 110–4. Jan 2007. doi:10.1111/j.1365-2265.2006.02694.x. PMID 17201809.
External links
- HDAC11+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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