Biology:Hepacivirin

From HandWiki
Hepacivirin
Identifiers
EC number3.4.21.98
CAS number149885-80-3
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

Hepacivirin (EC 3.4.21.98, Cpro-2, hepatitis C virus NS3 serine proteinase, NS3-4A serine proteinase complex) is an enzyme.[1][2] This enzyme catalyses the following chemical reaction:

Hydrolysis of four peptide bonds in the viral precursor polyprotein, commonly with Asp or Glu in the P6 position, Cys or Thr in P1 and Ser or Ala in P1'

This enzyme is encoded by the genome of the viruses of the hepatitis C group.

References

  1. "Crystal structure of the hepatitis C virus NS3 protease domain complexed with a synthetic NS4A cofactor peptide". Cell 87 (2): 343–55. October 1996. doi:10.1016/s0092-8674(00)81351-3. PMID 8861917. 
  2. Rice, C.M.; Rawlings, N.D.; Woessner, J.F. (1998). "Hepatitis C virus polyprotein peptidase". in Barrett, A.J.. Handbook of Proteolytic Enzymes. London: Academic Press. pp. 272–277. 

External links