Biology:KDM4C
From HandWiki
Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Lysine-specific demethylase 4C is an enzyme that in humans is encoded by the KDM4C gene.[1][2][3]
Function
This gene is a member of the Jumonji domain 2 (JMJD2) family and encodes a protein with one JmjC domain, one JmjN domain, two PHD-type zinc fingers, and two Tudor domains. This nuclear protein belongs to the alpha-ketoglutarate-dependent hydroxylase superfamily. It functions as a trimethylation-specific demethylase, converting specific trimethylated histone residues to the dimethylated form. Chromosomal aberrations and increased transcriptional expression of this gene are associated with esophageal squamous cell carcinoma.[3] A expressional decrease of KDM4C was found during cardiac differentation of murine embryonic stem cells.[4]
References
- ↑ "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research 5 (5): 277–86. Oct 1998. doi:10.1093/dnares/5.5.277. PMID 9872452.
- ↑ "Identification and characterization of JMJD2 family genes in silico". International Journal of Oncology 24 (6): 1623–8. Jun 2004. doi:10.3892/ijo.25.3.759. PMID 15138608.
- ↑ 3.0 3.1 "Entrez Gene: JMJD2C jumonji domain containing 2C". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23081.
- ↑ Boeckel, Jes-Niels; Derlet, Anja; Glaser, Simone F.; Luczak, Annika; Lucas, Tina; Heumüller, Andreas W.; Krüger, Marcus; Zehendner, Christoph M. et al. (July 2016). "JMJD8 Regulates Angiogenic Sprouting and Cellular Metabolism by Interacting With Pyruvate Kinase M2 in Endothelial Cells". Arteriosclerosis, Thrombosis, and Vascular Biology 36 (7): 1425–1433. doi:10.1161/ATVBAHA.116.307695. ISSN 1524-4636. PMID 27199445.
Further reading
- "Identification of a novel gene, GASC1, within an amplicon at 9p23-24 frequently detected in esophageal cancer cell lines". Cancer Research 60 (17): 4735–9. Sep 2000. PMID 10987278.
- "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Research 16 (1): 55–65. Jan 2006. doi:10.1101/gr.4039406. PMID 16344560.
- "Reversal of histone lysine trimethylation by the JMJD2 family of histone demethylases". Cell 125 (3): 467–81. May 2006. doi:10.1016/j.cell.2006.03.028. PMID 16603238.
- "The putative oncogene GASC1 demethylates tri- and dimethylated lysine 9 on histone H3". Nature 442 (7100): 307–11. Jul 2006. doi:10.1038/nature04837. PMID 16732293. Bibcode: 2006Natur.442..307C.
- "Cooperative demethylation by JMJD2C and LSD1 promotes androgen receptor-dependent gene expression". Nature Cell Biology 9 (3): 347–53. Mar 2007. doi:10.1038/ncb1546. PMID 17277772.
- "Comparative integromics on JMJD2A, JMJD2B and JMJD2C: preferential expression of JMJD2C in undifferentiated ES cells". International Journal of Molecular Medicine 20 (2): 269–73. Aug 2007. doi:10.3892/ijmm.20.2.269. PMID 17611647.
- "KDM4C and ATF4 Cooperate in Transcriptional Control of Amino Acid Metabolism". Cell Reports 14 (3): 506–519. 2016. doi:10.1016/j.celrep.2015.12.053. PMID 26774480.
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