Biology:Leukotriene C4 hydrolase
From HandWiki
| Leukotriene-C4 hydrolase | |||||||||
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| Identifiers | |||||||||
| EC number | 3.4.19.14 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
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Leukotriene-C4 hydrolase (EC 3.4.19.14, gamma-glutamyl leukotrienase) is an enzyme.[1][2][3][4] Gamma-glutamyltransferase 5 (GGT5) is a human gene which encodes an enzyme protein that belongs to this class of enzymes. This enzyme catalyses the following chemical reaction
- leukotriene C4 + H2O [math]\displaystyle{ \rightleftharpoons }[/math] leukotriene D4 + L-glutamate
The mouse enzyme is specific for leukotriene C4.
References
- ↑ "Metabolism of leukotriene C4 in gamma-glutamyl transpeptidase-deficient mice". The Journal of Biological Chemistry 272 (19): 12305–10. May 1997. doi:10.1074/jbc.272.19.12305. PMID 9139674.
- ↑ "Disruption of gamma-glutamyl leukotrienase results in disruption of leukotriene D(4) synthesis in vivo and attenuation of the acute inflammatory response". Molecular and Cellular Biology 21 (16): 5389–95. August 2001. doi:10.1128/mcb.21.16.5389-5395.2001. PMID 11463821.
- ↑ "Gamma-glutamyl leukotrienase, a novel endothelial membrane protein, is specifically responsible for leukotriene D(4) formation in vivo". The American Journal of Pathology 161 (2): 481–90. August 2002. doi:10.1016/s0002-9440(10)64204-6. PMID 12163373.
- ↑ "Gamma-glutamyl compounds: substrate specificity of gamma-glutamyl transpeptidase enzymes". Analytical Biochemistry 414 (2): 208–14. July 2011. doi:10.1016/j.ab.2011.03.026. PMID 21447318.
External links
- Leukotriene-C4+hydrolase at the US National Library of Medicine Medical Subject Headings (MeSH)
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