Biology:Limulus clotting factor B

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Limulus clotting factor B
Identifiers
EC number3.4.21.85
CAS number848851-53-6
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum

Limulus clotting factor B (EC 3.4.21.85) is an enzyme.[1] This enzyme catalyses the following chemical reaction

Selective cleavage of -Arg98-Ile- bond in limulus proclotting enzyme to form active clotting enzyme

From the hemocyte granules of the horseshoe crabs Limulus and Tachypleus. This enzyme is downstream of Limulus clotting factor C, but upstream of Limulus clotting enzyme.[2]

References

  1. "Purification and properties of intracellular clotting factor, factor B, from horseshoe crab (Tachypleus tridentatus) hemocytes". Journal of Biochemistry 99 (3): 847–57. March 1986. doi:10.1093/oxfordjournals.jbchem.a135545. PMID 3519594. 
  2. Iwanaga, S (May 2007). "Biochemical principle of Limulus test for detecting bacterial endotoxins.". Proceedings of the Japan Academy. Series B, Physical and Biological Sciences 83 (4): 110–9. doi:10.2183/pjab.83.110. PMID 24019589. Bibcode2007PJAB...83..110I. 

External links