Biology:Pantothenase

pantothenase
Identifiers
EC number	3.5.1.22
CAS number	9076-90-8
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

In enzymology, a pantothenase (EC 3.5.1.22) is an enzyme that catalyzes the chemical reaction

(R)-pantothenate + H₂O [math]\displaystyle{ \rightleftharpoons }[/math] (R)-pantoate + beta-alanine

Thus, the two substrates of this enzyme are (R)-pantothenate and H₂O, whereas its two products are (R)-pantoate and beta-alanine.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in linear amides. The systematic name of this enzyme class is (R)-pantothenate amidohydrolase. Other names in common use include pantothenate hydrolase, and pantothenate amidohydrolase. This enzyme participates in pantothenate and coa biosynthesis.

References

• "The bacterial degradation of pantothenic acid. II. Pantothenate hydrolase". Biochemistry 5 (2): 399–402. 1966. doi:10.1021/bi00866a002. PMID 5940928.