Chemistry:Cicletanine
From HandWiki
Short description: Chemical compound
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| AHFS/Drugs.com | International Drug Names |
| Routes of administration | Oral |
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| Protein binding | 97.3% |
| Elimination half-life | 7.9 h |
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| Chemical and physical data | |
| Formula | C14H12ClNO2 |
| Molar mass | 261.71 g·mol−1 |
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Cicletanine is a furopyridine low-ceiling diuretic drug, usually used in the treatment of hypertension.[1] The drug is manufactured by Ipsen and marketed by Recordati (in France) under the trade name Tenstaten.
It appears to be more potent in salt-sensitive hypertension.[2]
Mechanism
It can inhibit protein kinase C.[3]
References
- ↑ Genetic Hypertension. John Libbey Eurotext. 1992. ISBN 978-0-86196-313-3. https://books.google.com/books?id=v4E_g_D6xCwC&q=Cicletanine&pg=PA547.
- ↑ "Cicletanine reverses vasoconstriction induced by the endogenous sodium pump ligand, marinobufagenin, via a protein kinase C dependent mechanism". Journal of Hypertension 18 (2): 209–215. February 2000. doi:10.1097/00004872-200018020-00012. PMID 10694190. https://zenodo.org/record/1234808.
- ↑ "Myocardial PKC beta2 and the sensitivity of Na/K-ATPase to marinobufagenin are reduced by cicletanine in Dahl hypertension". Hypertension 41 (3): 505–511. March 2003. doi:10.1161/01.HYP.0000053446.43894.9F. PMID 12623951.
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