Chemistry:Potassium canrenoate
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Short description: Pharmaceutical drug
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| Clinical data | |
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| Other names | SC-14266 |
| AHFS/Drugs.com | International Drug Names |
| Routes of administration | Intravenous |
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| Pharmacokinetic data | |
| Metabolism | Hepatic |
| Excretion | Renal and fecal |
| Identifiers | |
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| DrugBank | |
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| ChEMBL | |
| Chemical and physical data | |
| Formula | C22H29KO4 |
| Molar mass | 396.568 g·mol−1 |
| 3D model (JSmol) | |
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Potassium canrenoate (INN, JAN) or canrenoate potassium (USAN) (brand names Venactone, Soldactone), also known as aldadiene kalium,[1] the potassium salt of canrenoic acid, is an aldosterone antagonist of the spirolactone group.[2] Like spironolactone, it is a prodrug, and is metabolized to active canrenone in the body.[3][4]
Potassium canrenoate is notable in that it is the only clinically used antimineralocorticoid which is available for parenteral administration (specifically intravenous)[4][5] as opposed to oral administration.[6]
In the UK, it is unlicensed and only used for short term diuresis in oedema or heart failure in neonates or children under specialist initiation and monitoring.
See also
References
- ↑ Hormones and Resistance: Part 1 and. Springer Science & Business Media. 17 April 2013. pp. 186–. ISBN 978-3-642-65192-2. https://books.google.com/books?id=NdvnCAAAQBAJ&pg=PA186.
- ↑ Dictionary of Steroids. CRC Press. 23 May 1991. pp. 656–. ISBN 978-0-412-27060-4. https://books.google.com/books?id=qw5X0NK1A90C&pg=PA656.
- ↑ Burger's Medicinal Chemistry and Drug Discovery: Therapeutic agents. Wiley. 1996. ISBN 978-0-471-57557-3. https://books.google.com/books?id=iLvwAAAAMAAJ.
- ↑ 4.0 4.1 "Diurectics and the Critical Ill". Oxford Desk Reference: Critical Care. OUP Oxford. 27 November 2008. pp. 187–. ISBN 978-0-19-922958-1. https://books.google.com/books?id=eLqMpXfAlEcC&pg=PA187.
- ↑ "Non-resection: Radiofrequency Ablation, Cryo, Microwave". Surgical Principles of Minimally Invasive Procedures: Manual of the European Association of Endoscopic Surgery (EAES). Springer. 21 June 2017. pp. 136–. ISBN 978-3-319-43196-3. https://books.google.com/books?id=tAImDwAAQBAJ&pg=PA136.
- ↑ "30 YEARS OF THE MINERALOCORTICOID RECEPTOR: Mineralocorticoid receptor antagonists: 60 years of research and development". The Journal of Endocrinology 234 (1): T125–T140. July 2017. doi:10.1530/JOE-16-0600. PMID 28634268.
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