Chemistry:Hydroflumethiazide

Hydroflumethiazide
Clinical data
AHFS/Drugs.com	Micromedex Detailed Consumer Information
ATC code	C03AA02 (WHO) ;
Identifiers
	IUPAC name 1,1-Dioxo-6-(trifluoromethyl)-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide;
CAS Number	135-09-1 ;
PubChem CID	3647;
IUPHAR/BPS	7197;
DrugBank	DB00774 ;
ChemSpider	3521 ;
UNII	501CFL162R;
KEGG	D00654 ;
ChEMBL	ChEMBL1763 ;
Chemical and physical data
Formula	C8H8F3N3O4S2
Molar mass	331.28 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES FC(F)(F)c2c(cc1c(NCNS1(=O)=O)c2)S(=O)(=O)N;
	InChI InChI=1S/C8H8F3N3O4S2/c9-8(10,11)4-1-5-7(2-6(4)19(12,15)16)20(17,18)14-3-13-5/h1-2,13-14H,3H2,(H2,12,15,16) ; Key:DMDGGSIALPNSEE-UHFFFAOYSA-N ;
	(verify)

Short description: Chemical compound

Hydroflumethiazide (or Saluron) is a diuretic.

Synthesis

Hydroflumethiazide synthesis:^[1]^[2]^[3] Numerous patents, e.g., Lund et al., U.S. Patent 3,254,076 (1966 to Lövens Kemiske Fabrik).

↑ "Synthesis of Trifluoromethylated Compounds Possessing Diuretic Activity1". Journal of the American Chemical Society 81 (18): 4807–4810. 1959. doi:10.1021/ja01527a015.
↑ "Synthesis of Potential Diuretic Agents. I. Derivatives of 7-Sulfamyl-3,4-dihydro-1,2,4-benzothiadiazine 1,1-Dioxide". Journal of the American Chemical Society 82 (5): 1132–1135. 1960. doi:10.1021/ja01490a028.
↑ "Diuretics: 1,2,4-Benzothiadiazine-1,1-dioxides". The Journal of Organic Chemistry 25 (6): 970–981. 1960. doi:10.1021/jo01076a028.

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v t e Symporter inhibitors
Na⁺-Cl⁻	Thiazides: Bendroflumethiazide Chlorothiazide Cyclopenthiazide Cyclothiazide Hydrochlorothiazide Hydroflumethiazide Methyclothiazide Polythiazide Trichlormethiazide; Others: Chlortalidone (chlorthalidone) Metolazone
Na⁺-K⁺-Cl⁻	Bumetanide Furosemide
See also: Receptor/signaling modulators