Biology:Sialidase-3

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Short description: Protein-coding gene in the species Homo sapiens


A representation of the 3D structure of the protein myoglobin showing turquoise α-helices.
Generic protein structure example

Sialidase-3 is an enzyme that in humans is encoded by the NEU3 gene.[1][2]

Function

This gene product belongs to a family of glycohydrolytic enzymes which remove sialic acid residues from glycoproteins and glycolipids. It is localized in the plasma membrane, and its activity is specific for gangliosides. It may play a role in modulating the ganglioside content of the lipid bilayer.[2]

Interactions

Sialidase-3 has been shown to interact with Grb2.[3]

References

  1. "Cloning, expression, and chromosomal mapping of a human ganglioside sialidase". Biochem Biophys Res Commun 261 (1): 21–7. Aug 1999. doi:10.1006/bbrc.1999.0973. PMID 10405317. 
  2. 2.0 2.1 "Entrez Gene: NEU3 sialidase 3 (membrane sialidase)". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10825. 
  3. "Overexpression of plasma membrane-associated sialidase attenuates insulin signaling in transgenic mice". J. Biol. Chem. 278 (30): 27896–902. Jul 2003. doi:10.1074/jbc.M212200200. PMID 12730204. 

Further reading