Biology:ADARB1
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Double-stranded RNA-specific editase 1 is an enzyme that in humans is encoded by the ADARB1 gene.[1][2][3] The enzyme is a member of ADAR family.
Function
This gene encodes the enzyme responsible for pre-mRNA editing of the glutamate receptor subunit B by site-specific deamination of adenosines. Studies in rats found that this enzyme acted on its own pre-mRNA molecules to convert an AA dinucleotide to an AI dinucleotide which resulted in a new splice site. Alternative splicing of this gene results in several transcript variants, some of which have been characterized by the presence or absence of an Alu cassette insert and a short or long C-terminal region.[3]
ADARB1 requires the small molecule inositol hexakisphosphate (IP6) for proper function.[4] ADARB1 is an A-to-I RNA-editing enzyme that mostly acts on protein-coding substrates.[5]
See also
- Adenosine deaminase (ADA), an enzyme acting on isolated adenosine
References
- ↑ "Cloning of a human RNA editing deaminase (ADARB1) of glutamate receptors that maps to chromosome 21q22.3". Genomics 41 (2): 210–7. April 1997. doi:10.1006/geno.1997.4655. PMID 9143496.
- ↑ "Adenosine deaminases acting on RNA (ADARs): RNA-editing enzymes". Genome Biology 5 (2): 209. Feb 2004. doi:10.1186/gb-2004-5-2-209. PMID 14759252.
- ↑ 3.0 3.1 "Entrez Gene: ADARB1 adenosine deaminase, RNA-specific, B1 (RED1 homolog rat)". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=104.
- ↑ "Inositol hexakisphosphate is bound in the ADAR2 core and required for RNA editing". Science 309 (5740): 1534–9. September 2005. doi:10.1126/science.1113150. PMID 16141067. Bibcode: 2005Sci...309.1534M.
- ↑ "Rapid and dynamic transcriptome regulation by RNA editing and RNA modifications". The Journal of Cell Biology 213 (1): 15–22. April 2016. doi:10.1083/jcb.201511041. PMID 27044895.
Further reading
- "HIV-1 Envelope gp120 and Viral Particles Block Adenosine Deaminase Binding to Human CD26". Cellular Peptidases in Immune Functions and Diseases. Advances in Experimental Medicine and Biology. 421. 1997. pp. 185–92. doi:10.1007/978-1-4757-9613-1_24. ISBN 978-1-4757-9615-5.
- "A mammalian RNA editing enzyme". Nature 379 (6564): 460–4. February 1996. doi:10.1038/379460a0. PMID 8559253. Bibcode: 1996Natur.379..460M.
- "Purification of human double-stranded RNA-specific editase 1 (hRED1) involved in editing of brain glutamate receptor B pre-mRNA". The Journal of Biological Chemistry 272 (1): 473–8. January 1997. doi:10.1074/jbc.272.1.473. PMID 8995285.
- "Adenosine deaminase binding to human CD26 is inhibited by HIV-1 envelope glycoprotein gp120 and viral particles". Journal of Immunology 158 (8): 3721–9. April 1997. doi:10.4049/jimmunol.158.8.3721. PMID 9103436.
- "Editing of glutamate receptor B subunit ion channel RNAs by four alternatively spliced DRADA2 double-stranded RNA adenosine deaminases". Molecular and Cellular Biology 17 (5): 2413–24. May 1997. doi:10.1128/MCB.17.5.2413. PMID 9111310.
- "Purification and characterization of a human RNA adenosine deaminase for glutamate receptor B pre-mRNA editing". Proceedings of the National Academy of Sciences of the United States of America 94 (9): 4354–9. April 1997. doi:10.1073/pnas.94.9.4354. PMID 9113993. Bibcode: 1997PNAS...94.4354Y.
- "Two forms of human double-stranded RNA-specific editase 1 (hRED1) generated by the insertion of an Alu cassette". RNA 3 (5): 453–63. May 1997. PMID 9149227.
- "Map location, genomic organization and expression patterns of the human RED1 RNA editase". Somatic Cell and Molecular Genetics 23 (2): 135–45. March 1997. doi:10.1007/BF02679972. PMID 9330641.
- "The HIV-1 gp120 inhibits the binding of adenosine deaminase to CD26 by a mechanism modulated by CD4 and CXCR4 expression". FEBS Letters 477 (1–2): 123–8. July 2000. doi:10.1016/S0014-5793(00)01751-8. PMID 10899322.
- "Comodulation of CXCR4 and CD26 in human lymphocytes". The Journal of Biological Chemistry 276 (22): 19532–9. June 2001. doi:10.1074/jbc.M004586200. PMID 11278278.
- "Underediting of glutamate receptor GluR-B mRNA in malignant gliomas". Proceedings of the National Academy of Sciences of the United States of America 98 (25): 14687–92. December 2001. doi:10.1073/pnas.251531398. PMID 11717408. Bibcode: 2001PNAS...9814687M.
- "Increased RNA editing and inhibition of hepatitis delta virus replication by high-level expression of ADAR1 and ADAR2". Journal of Virology 76 (8): 3819–27. April 2002. doi:10.1128/JVI.76.8.3819-3827.2002. PMID 11907222.
- "Adenosine to inosine editing by ADAR2 requires formation of a ternary complex on the GluR-B R/G site". The Journal of Biological Chemistry 277 (40): 37624–9. October 2002. doi:10.1074/jbc.M204126200. PMID 12163487.
- "Inhibition of hepatitis delta virus RNA editing by short inhibitory RNA-mediated knockdown of ADAR1 but not ADAR2 expression". Journal of Virology 76 (23): 12399–404. December 2002. doi:10.1128/JVI.76.23.12399-12404.2002. PMID 12414985.
- "Phylogenetic comparison of the pre-mRNA adenosine deaminase ADAR2 genes and transcripts: conservation and diversity in editing site sequence and alternative splicing patterns". Gene 299 (1–2): 83–94. October 2002. doi:10.1016/S0378-1119(02)01016-8. PMID 12459255.
External links
- Human ADARB1 genome location and ADARB1 gene details page in the UCSC Genome Browser.
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