Biology:GBA2
From HandWiki
Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
GBA2 is the gene that encodes the enzyme non-lysosomal glucosylceramidase in humans.[1][2] It has glucosylceramidase (EC 3.2.1.45) activity.
Function
This gene encodes a microsomal beta-glucosidase that catalyzes the hydrolysis of bile acid 3-O-glucosides as endogenous compounds. Studies to determine subcellular localization of this protein in the liver indicated that the enzyme was mainly enriched in the microsomal fraction where it appeared to be confined to the endoplasmic reticulum. This putative transmembrane protein is thought to play a role in carbohydrate transport and metabolism.[2]
See also
- Closely related enzymes
References
- ↑ "Molecular cloning and expression of human bile acid beta-glucosidase". J Biol Chem 276 (41): 37929–33. Oct 2001. doi:10.1074/jbc.M104290200. PMID 11489889.
- ↑ 2.0 2.1 "Entrez Gene: GBA2 glucosidase, beta (bile acid) 2". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=57704.
Further reading
- "Folding of the human immunodeficiency virus type 1 envelope glycoprotein in the endoplasmic reticulum". Biochimie 83 (8): 783–90. 2001. doi:10.1016/S0300-9084(01)01314-1. PMID 11530211.
- "AIDS and glycosylation". Glycobiology 1 (1): 17–23. 1992. doi:10.1093/glycob/1.1.17. PMID 2136376.
- "Identification of the non-lysosomal glucosylceramidase as beta-glucosidase 2". J. Biol. Chem. 282 (2): 1305–12. 2007. doi:10.1074/jbc.M610544200. PMID 17105727.
- "N-Glycans in the gp120 V1/V2 domain of the HIV-1 strain NL4-3 are indispensable for viral infectivity and resistance against antibody neutralization". Med. Microbiol. Immunol. 195 (3): 165–72. 2007. doi:10.1007/s00430-006-0016-z. PMID 16547752.
- "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "DNA sequence and analysis of human chromosome 9". Nature 429 (6990): 369–74. 2004. doi:10.1038/nature02465. PMID 15164053. Bibcode: 2004Natur.429..369H.
- "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. 2004. doi:10.1038/ng1285. PMID 14702039.
- "Hyperglycosylated Mutants of Human Immunodeficiency Virus (HIV) Type 1 Monomeric gp120 as Novel Antigens for HIV Vaccine Design". J. Virol. 77 (10): 5889–901. 2003. doi:10.1128/JVI.77.10.5889-5901.2003. PMID 12719582.
- "Glycosylation inhibitors and neuraminidase enhance human immunodeficiency virus type 1 binding and neutralization by mannose-binding lectin". J. Gen. Virol. 84 (Pt 2): 353–60. 2003. doi:10.1099/vir.0.18734-0. PMID 12560567.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (4): 273–81. 2001. doi:10.1093/dnares/7.4.271. PMID 10997877.
- "Purification and characterization of a microsomal bile acid beta-glucosidase from human liver". J. Biol. Chem. 272 (17): 11261–7. 1997. doi:10.1074/jbc.272.17.11261. PMID 9111029.
- "Effect of various glycosidase treatments on the resistance of the HIV-1 envelope to degradation". FEBS Lett. 406 (1–2): 191–5. 1997. doi:10.1016/S0014-5793(97)00273-1. PMID 9109416.
- "Influence of N-linked glycans in V4-V5 region of human immunodeficiency virus type 1 glycoprotein gp160 on induction of a virus-neutralizing humoral response". J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. 12 (3): 213–20. 1996. doi:10.1097/00042560-199607000-00001. PMID 8673525.
- "Site-specific N-glycosylation and oligosaccharide structures of recombinant HIV-1 gp120 derived from a baculovirus expression system". Biochemistry 32 (41): 11087–99. 1993. doi:10.1021/bi00092a019. PMID 8218172.
- "Functional role of the glycan cluster of the human immunodeficiency virus type 1 transmembrane glycoprotein (gp41) ectodomain". J. Virol. 67 (1): 150–60. 1993. doi:10.1128/jvi.67.1.150-160.1993. PMID 8093218.
- "Role of protein N-glycosylation in pathogenesis of human immunodeficiency virus type 1". Proc. Natl. Acad. Sci. U.S.A. 85 (23): 9248–52. 1988. doi:10.1073/pnas.85.23.9248. PMID 3264072. Bibcode: 1988PNAS...85.9248M.
- "Glycosylation inhibitors block the expression of LAV/HTLV-III (HIV) glycoproteins". Biochem. Biophys. Res. Commun. 141 (1): 33–8. 1987. doi:10.1016/S0006-291X(86)80330-8. PMID 3099781.
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