Biology:Methanofuran
Methanofurans (MFRs) are a family of chemical compounds found in methanogenic archaea.[1] These species feature a 2-aminomethylfuran linked to phenoxy group. At least three different end groups are recognized: R = tricarboxyheptanoyl (methanofuran), glutamyl-glutamyl (methanofuran b), tricarboxy-2-hydroxyheptanoyl (methanofuran c, see picture).
Formylation of MFR
Methanofuran converts to formylmethanofuran in an early stage of methanogenesis. The enzyme formylmethanofuran dehydrogenase (EC: 1.2.99.5) formylates methanofuran using CO2, the primary C1 source in methanogenesis.[2]
Deformylation of MFR
The enzyme formylmethanofuran:tetrahydromethanopterin formyltransferase catalyzes the transfer of the formyl group from formylmethanofuran to N5 on tetrahydromethanopterin, H4MPT. This enzyme has been crystallized; it contains no prosthetic group.[3]
References
- ↑ Thauer RK (September 1998). "Biochemistry of methanogenesis: a tribute to Marjory Stephenson. 1998 Marjory Stephenson Prize Lecture". Microbiology 144 (Pt 9): 2377–406. doi:10.1099/00221287-144-9-2377. PMID 9782487. http://mic.sgmjournals.org/cgi/pmidlookup?view=long&pmid=9782487.
- ↑ "The active species of CO2 utilized by formylmethanofuran dehydrogenase from methanogenic Archaea". Eur. J. Biochem. 248 (3): 919–24. September 1997. doi:10.1111/j.1432-1033.1997.00919.x. PMID 9342247.
- ↑ "The structure of formylmethanofuran: tetrahydromethanopterin formyltransferase in complex with its coenzymes". J. Mol. Biol. 357 (3): 870–9. March 2006. doi:10.1016/j.jmb.2006.01.015. PMID 16466742.
 |  |
