Biology:NEU3
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Sialidase-3 is an enzyme that in humans is encoded by the NEU3 gene.[1][2]
Function
This gene product belongs to a family of glycohydrolytic enzymes which remove sialic acid residues from glycoproteins and glycolipids. It is localized in the plasma membrane, and its activity is specific for gangliosides. It may play a role in modulating the ganglioside content of the lipid bilayer.[2]
Interactions
NEU3 has been shown to interact with Grb2.[3]
References
- ↑ "Cloning, expression, and chromosomal mapping of a human ganglioside sialidase". Biochem Biophys Res Commun 261 (1): 21–7. Aug 1999. doi:10.1006/bbrc.1999.0973. PMID 10405317.
- ↑ 2.0 2.1 "Entrez Gene: NEU3 sialidase 3 (membrane sialidase)". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10825.
- ↑ "Overexpression of plasma membrane-associated sialidase attenuates insulin signaling in transgenic mice". J. Biol. Chem. 278 (30): 27896–902. Jul 2003. doi:10.1074/jbc.M212200200. PMID 12730204.
Further reading
- "Infectivities of human and other primate lentiviruses are activated by desialylation of the virion surface". J. Virol. 70 (11): 7462–70. 1996. doi:10.1128/JVI.70.11.7462-7470.1996. PMID 8892864.
- "Identification and expression of NEU3, a novel human sialidase associated to the plasma membrane". Biochem. J. 349 (Pt 1): 343–51. 2001. doi:10.1042/0264-6021:3490343. PMID 10861246.
- "A close association of the ganglioside-specific sialidase Neu3 with caveolin in membrane microdomains". J. Biol. Chem. 277 (29): 26252–9. 2002. doi:10.1074/jbc.M110515200. PMID 12011038.
- "Up-regulation of plasma membrane-associated ganglioside sialidase (Neu3) in human colon cancer and its involvement in apoptosis suppression". Proc. Natl. Acad. Sci. U.S.A. 99 (16): 10718–23. 2002. doi:10.1073/pnas.152597199. PMID 12149448. Bibcode: 2002PNAS...9910718K.
- "High mannose glycans and sialic acid on gp120 regulate binding of mannose-binding lectin (MBL) to HIV type 1". AIDS Res. Hum. Retroviruses 18 (17): 1311–7. 2003. doi:10.1089/088922202320886352. PMID 12487819.
- "Substrate specificity and inhibitor studies of a membrane-bound ganglioside sialidase isolated from human brain tissue". Biol. Chem. 383 (11): 1735–42. 2003. doi:10.1515/BC.2002.194. PMID 12530538.
- "Overexpression of plasma membrane-associated sialidase attenuates insulin signaling in transgenic mice". J. Biol. Chem. 278 (30): 27896–902. 2003. doi:10.1074/jbc.M212200200. PMID 12730204.
- "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. 2005. doi:10.1038/nbt971. PMID 15146197.
- "Molecular characterization of membrane type and ganglioside-specific sialidase (Neu3) expressed in E. coli". Mol. Cells 17 (2): 267–73. 2004. PMID 15179041.
- "Differential expression of endogenous sialidases of human monocytes during cellular differentiation into macrophages". FEBS J. 272 (10): 2545–56. 2005. doi:10.1111/j.1742-4658.2005.04679.x. PMID 15885103.
- "Plasma-membrane-associated sialidase (NEU3) differentially regulates integrin-mediated cell proliferation through laminin- and fibronectin-derived signalling". Biochem. J. 394 (Pt 3): 647–56. 2006. doi:10.1042/BJ20050737. PMID 16241905.
- "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. 2006. doi:10.1101/gr.4039406. PMID 16344560.
- "Plasma membrane-associated sialidase is up-regulated in renal cell carcinoma and promotes interleukin-6-induced apoptosis suppression and cell motility". J. Biol. Chem. 281 (12): 7756–64. 2006. doi:10.1074/jbc.M509668200. PMID 16428383.
- "Epidermal growth factor-induced mobilization of a ganglioside-specific sialidase (NEU3) to membrane ruffles". Biochem. Biophys. Res. Commun. 346 (2): 484–90. 2006. doi:10.1016/j.bbrc.2006.05.136. PMID 16765317.
- "Sialidase expression in activated human T lymphocytes influences production of IFN-gamma". J. Leukoc. Biol. 81 (1): 284–96. 2007. doi:10.1189/jlb.1105692. PMID 17028199.
- "Increased hepatic expression of ganglioside-specific sialidase, NEU3, improves insulin sensitivity and glucose tolerance in mice". Metab. Clin. Exp. 56 (3): 420–9. 2007. doi:10.1016/j.metabol.2006.10.027. PMID 17292733.
- "A crucial role of plasma membrane-associated sialidase in the survival of human cancer cells". Oncogene 26 (17): 2483–90. 2007. doi:10.1038/sj.onc.1210341. PMID 17334392.
- "Enhanced expression of membrane-associated sialidase Neu3 decreases GD3 and increases GM3 on the surface of Jurkat cells during etoposide-induced apoptosis". Biol. Pharm. Bull. 30 (9): 1680–4. 2007. doi:10.1248/bpb.30.1680. PMID 17827720.
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