Medicine:MMR vaccine

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Short description: Any of several combined vaccines against measles, mumps, and rubella
MMR vaccine
Priorix.jpg
An MMR vaccine kit
Combination of
Measles vaccineVaccine
Mumps vaccineVaccine
Rubella vaccineVaccine
Clinical data
Trade namesM-M-R II, Priorix, Tresivac, others
Other namesMPR vaccine[1]
AHFS/Drugs.comProfessional Drug Facts
MedlinePlusa601176
License data
Pregnancy
category
  • AU: B2[2]
  • US: C (Risk not ruled out)[2]
ATC code
Legal status
Legal status
  • AU: S4 (Prescription only)
  • UK: POM (Prescription only)
  • US: ℞-only
  • EU: Rx-only [3]
  • In general: ℞ (Prescription only)
Identifiers
CAS Number
ChemSpider
  • None
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The MMR vaccine is a vaccine against measles, mumps, and rubella (German measles).[4] The first dose is generally given to children around 9 months to 15 months of age, with a second dose at 15 months to 6 years of age, with at least 4 weeks between the doses.[5][6] After two doses, 97% of people are protected against measles, 88% against mumps, and at least 97% against rubella.[5] The vaccine is also recommended for those who do not have evidence of immunity,[5] those with well-controlled HIV/AIDS,[7][8] and within 72 hours of exposure to measles among those who are incompletely immunized.[6] It is given by injection.[5]

The MMR vaccine is widely used around the world, with over 500 million doses having been given in over 100 countries as of 2001.[9][10] Measles resulted in 2.6 million deaths per year before immunization became common.[10] This has decreased to 122,000 deaths per year (As of 2012), mostly in low-income countries.[10] Through vaccination, (As of 2018), rates of measles in North and South America are very low.[10] Rates of disease have been seen to increase in populations that go unvaccinated.[10] Between 2000 and 2016, vaccination decreased measles deaths by a further 84%.[11]

Side effects of immunization are generally mild and go away without any specific treatment.[12] These may include fever, as well as pain or redness at the injection site.[12] Severe allergic reactions occur in about one in a million people.[12] Because it contains live viruses, the MMR vaccine is not recommended during pregnancy but may be given while breastfeeding.[5] The vaccine is safe to give at the same time as other vaccines.[12] Being recently immunized does not increase the risk of passing measles, mumps, or rubella on to others.[5] Vaccination does not increase the risk of autism.[13][14][15] The MMR vaccine is a mixture of live weakened viruses of the three diseases.[5]

The MMR vaccine was developed by Maurice Hilleman.[4] It was licensed for use in USA by Merck in 1971.[16] Stand-alone measles, mumps, and rubella vaccines had been previously licensed in 1963, 1967, and 1969, respectively.[16][17] Recommendations for a second dose were introduced in 1989.[16] The MMRV vaccine, which also covers chickenpox, may be used instead.[5] An MR vaccine, without coverage for mumps, is also occasionally used.[18]

Medical use

In 2020, Cochrane concluded "Existing evidence on the safety and effectiveness of MMR vaccine supports current policies of mass immunisation aimed at global measles eradication and in order to reduce morbidity and mortality associated with mumps and rubella."[13]

The combined MMR vaccine induces immunity less painfully than three separate injections at the same time, and sooner and more efficiently than three injections given on different dates. Public Health England reports that providing a single combined vaccine as of 1988, rather than giving the option to have them also done separately, increased uptake of the vaccine.[19]

Measles

Measles cases 1944-1963 followed a highly variable epidemic pattern, with 150,000-850,000 cases reported per year. A sharp decline followed introduction of the first measles vaccine in 1963, with fewer than 25,000 cases reported in 1968. Outbreaks around 1971 and 1977 gave 75,000 and 57,000 cases, respectively. Cases were stable at a few thousand per year until an outbreak of 28,000 in 1990. Cases declined from a few hundred per year in the early 1990s to a few dozen in the 2000s.
Measles cases reported in the United States fell dramatically after introduction of the measles vaccine.

Before the widespread use of a vaccine against measles, rates of disease were so high that infection was felt to be "as inevitable as death and taxes."[20] Reported cases of measles in the United States fell from hundreds of thousands to tens of thousands per year following introduction of the vaccine in 1963. Increasing uptake of the vaccine following outbreaks in 1971, and 1977, brought this down to thousands of cases per year in the 1980s. An outbreak of almost 30,000 cases in 1990 led to a renewed push for vaccination and the addition of a second vaccine to the recommended schedule. Fewer than 200 cases have been reported in the U.S. each year between 1997 and 2013, and the disease is no longer considered endemic there.[21][22][23]

The benefit of measles vaccination in preventing illness, disability, and death has been well documented. The first 20 years of licensed measles vaccination in the U.S. prevented an estimated 52 million cases of the disease, 17,400 cases of intellectual disability, and 5,200 deaths.[24] During 1999–2004, a strategy led by the World Health Organization and UNICEF led to improvements in measles vaccination coverage that averted an estimated 1.4 million measles deaths worldwide.[25] Between 2000 and 2013, measles vaccination resulted in a 75% decrease in deaths from the disease.[26]

Measles is common in many areas of the world. Although it was declared eliminated from the U.S. in 2000, high rates of vaccination and good communication with persons who refuse vaccination are needed to prevent outbreaks and sustain the elimination of measles in the U.S.[27] Of the 66 cases of measles reported in the U.S. in 2005, slightly over half were attributable to one unvaccinated individual who acquired measles during a visit to Romania.[28] This individual returned to a community with many unvaccinated children. The resulting outbreak infected 34 people, mostly children and virtually all unvaccinated; 9% were hospitalized, and the cost of containing the outbreak was estimated at $167,685. A major epidemic was averted due to high rates of vaccination in the surrounding communities.[27]

In 2017, an outbreak of measles occurred among the Somali-American community in Minnesota, where MMR vaccination rates had declined due to the misconception that the vaccine could cause autism. The Centers for Disease Control and Prevention recorded 65 affected children in the outbreak by April 10, 2017.[29]

Rubella

Rubella rates fell sharply in the United States when immunization was introduced.

Rubella, also known as German measles, was also very common before widespread vaccination. The major risk of rubella is during pregnancy when the baby may contract congenital rubella, which can cause significant congenital defects.[30]

Mumps

Mumps is another viral disease that was once very common, especially during childhood. If mumps is acquired by a male who is past puberty, a possible complication is bilateral orchitis, which can in some cases lead to sterility.[31]

Administration

The MMR vaccine is administered by a subcutaneous injection. The second dose may be given as early as one month after the first dose.[32] The second dose is a dose to produce immunity in the small number of persons (2–5%) who fail to develop measles immunity after the first dose. In the U.S. it is done before entry to kindergarten because that is a convenient time.[33] Areas where measles is common typically recommend the first dose at 9 months of age and the second dose at 15 months of age.[6]

Safety

Adverse reactions, rarely serious, may occur from each component of the MMR vaccine. Ten percent of children develop fever, malaise, and a rash 5–21 days after the first vaccination;[34] and 3% develop joint pain lasting 18 days on average.[35] Older women appear to be more at risk of joint pain, acute arthritis, and even (rarely) chronic arthritis.[36] Anaphylaxis is an extremely rare but serious allergic reaction to the vaccine.[37] One cause can be egg allergy.[38] In 2014, the FDA approved two additional possible adverse events on the vaccination label: acute disseminated encephalomyelitis (ADEM), and transverse myelitis, with permission to also add "difficulty walking" to the package inserts.[39] A 2012 IOM report found that the measles component of the MMR vaccine can cause measles inclusion body encephalitis in immunocompromised individuals. This report also rejected any connection between the MMR vaccine and autism.[40] Some versions of the vaccine contain the antibiotic neomycin and therefore should not be used in people allergic to this antibiotic.[15]

The number of reports on neurological disorders is very small, other than evidence for an association between a form of the MMR vaccine containing the Urabe mumps strain and rare adverse events of aseptic meningitis, a form of viral meningitis.[36][41] The UK National Health Service stopped using the Urabe mumps strain in the early 1990s due to cases of transient mild viral meningitis, and switched to a form using the Jeryl Lynn mumps strain instead.[42] The Urabe strain remains in use in a number of countries; MMR with the Urabe strain is much cheaper to manufacture than with the Jeryl Lynn strain,[43] and a strain with higher efficacy along with a somewhat higher rate of mild side effects may still have the advantage of reduced incidence of overall adverse events.[42]

A Cochrane review found that, compared with placebo, MMR vaccine was associated with fewer upper respiratory tract infections, more irritability, and a similar number of other adverse effects.[13]

Naturally acquired measles often occurs with immune thrombocytopenic purpura (ITP, a purpuric rash and an increased tendency to bleed that resolves within two months in children), occurring in 1 to 20,000 cases.[13] Approximately 1 in 40,000 children are thought to acquire ITP in the six weeks following an MMR vaccination.[13] ITP below the age of six years is generally a mild disease, rarely having long-term consequences.[44][45]

False claims about autism

Main page: Social:MMR vaccine and autism

In 1998 Andrew Wakefield et al. published a fraudulent paper about twelve children, reportedly with bowel symptoms and autism or other disorders acquired soon after administration of MMR vaccine,[46] while supporting a competing vaccine. In 2010, Wakefield's research was found by the General Medical Council to have been "dishonest",[47] and The Lancet fully retracted the paper.[48] Three months following The Lancet's retraction, Wakefield was struck off the UK medical register, with a statement identifying deliberate falsification in the research published in The Lancet,[49] and was barred from practising medicine in the UK.[50] The research was declared fraudulent in 2011 by the British Medical Journal.[51]

Since Wakefield's publication, multiple peer-reviewed studies have failed to show any association between the vaccine and autism.[13][52] The Centers for Disease Control and Prevention,[53] the Institute of Medicine of the National Academy of Sciences,[54] the UK National Health Service[55] and the Cochrane Library review[13] have all concluded that there is no evidence of a link.

Administering the vaccines in three separate doses does not reduce the chance of adverse effects, and it increases the opportunity for infection by the two diseases not immunized against first.[52][56] Health experts have criticized media reporting of the MMR-autism controversy for triggering a decline in vaccination rates.[57] Before publication of Wakefield's findings, the inoculation rate for MMR in the UK was 92%; after publication, the rate dropped to below 80%. In 1998, there were 56 measles cases in the UK; by 2008, there were 1348 cases, with two confirmed deaths.[58]

In Japan, the MMR triplet is not used. Immunity is achieved by a combination vaccine for measles and rubella, followed up later with a mumps only vaccine. This has had no effect on autism rates in the country, further disproving the MMR autism hypothesis.[59]

History

Maurice Hilleman, who developed the MMR vaccine
Two workers make openings in chicken eggs in preparation for a measles vaccine

The component viral strains of MMR vaccine were developed by propagation in animal and human cells as all viruses require a living host cell to replicate.

For example, in the case of mumps and measles viruses, the virus strains were grown in embryonated chicken eggs. This produced strains of virus which were adapted for chicken cells and less well-suited for human cells. These strains are therefore called attenuated strains. They are sometimes referred to as neuroattenuated because these strains are less virulent to human neurons than the wild strains.

The Rubella component, Meruvax, was developed in 1967 through propagation using the human embryonic lung cell line WI-38 (named for the Wistar Institute) that was derived six years earlier in 1961.[60][61]

Disease immunized Component vaccine Virus strain Propagation medium Growth medium
Measles Attenuvax Enders' attenuated Edmonston strain[62] chick embryo cell culture Medium 199
Mumps Mumpsvax[63] Jeryl Lynn (B level) strain[64]
Rubella Meruvax II Wistar RA 27/3 strain of live attenuated rubella virus WI-38 human embryonic cell line MEM (solution containing buffered salts, fetal bovine serum, human serum albumin and neomycin, etc.)

The term "MPR vaccine" is also used to refer to this vaccine, whereas "P" refer to Parotitis which caused by mumps.[1]

Merck MMR II is supplied freeze-dried (lyophilized) and contains live viruses. Before injection it is reconstituted with the solvent provided.[65]

According to a review published in 2018, the GlaxoSmithKline (GSK) MMR vaccine known as Pluserix "contains the Schwarz measles virus, the Jeryl Lynn–like mumps strain, and RA27/3 rubella virus".[66]

Pluserix was introduced to the Hungarians in 1999.[67] Enders’ Edmonston strain has been used since 1999 in Hungary in Merck MMR II product.[67] GSK PRIORIX vaccine, which uses attenuated Schwarz Measles, was introduced to Hungarians in 2003.[67]

MMRV vaccine

Main page: Medicine:MMRV vaccine

The MMRV vaccine, a combined measles, mumps, rubella and varicella (chickenpox) vaccine, has been proposed as a replacement for the MMR vaccine to simplify administration of the vaccines.[32] Preliminary data indicate a rate of febrile seizures of 9 per 10,000 vaccinations with MMRV, as opposed to 4 per 10,000 for separate MMR and varicella shots; U.S. health officials therefore do not express a preference for use of MMRV vaccine over separate injections.[68]

In a 2012 study[69] pediatricians and family doctors were sent a survey to gauge their awareness of the increased risk of febrile seizures (fever fits) in the MMRV. 74% of family doctors and 29% of pediatricians were unaware of the increased risk of febrile seizures. After reading an informational statement only 7% of family doctors and 20% of pediatricians would recommend the MMRV for a healthy 12- to 15-month-old child. The factor that was reported as the "most important" deciding factor in recommending the MMRV over the MMR+V was ACIP/AAFP/AAP recommendations (pediatricians, 77%; family physicians, 73%).

MR vaccine

This is a vaccine that covers measles and rubella but not mumps.[18] As of 2014, it was used in a "few (unidentified) countries".[18]

Religious concerns

Some brands of this vaccine use gelatine, derived from domestic pigs, as a stabilizer. This has caused reduced take-up, and consequent increased levels of disease, among communities with a high proportion of Muslims or Orthodox Jews.[70][71]

References

  1. ↑ 1.0 1.1 Grignolio, Andrea (2018). Vaccines: Are they Worth a Shot?. Springer. p. 2. ISBN 9783319681061. https://books.google.com/books?id=hgFkDwAAQBAJ&pg=PA2. 
  2. ↑ 2.0 2.1 "Measles virus vaccine / mumps virus vaccine / rubella virus vaccine (M-M-R II) Use During Pregnancy". 16 October 2019. https://www.drugs.com/pregnancy/measles-virus-vaccine-mumps-virus-vaccine-rubella-virus-vaccine.html. 
  3. ↑ "M-M-RVaxPro EPAR". https://www.ema.europa.eu/en/medicines/human/EPAR/m-m-rvaxpro. 
  4. ↑ 4.0 4.1 "Maurice R. Hilleman, PhD, DSc". Seminars in Pediatric Infectious Diseases 16 (3): 225–226. July 2005. doi:10.1053/j.spid.2005.05.002. PMID 16044396. 
  5. ↑ 5.0 5.1 5.2 5.3 5.4 5.5 5.6 5.7 "Measles, Mumps, and Rubella (MMR) Vaccination: What Everyone Should Know". 26 January 2021. https://www.cdc.gov/vaccines/vpd/mmr/public/index.html. 
  6. ↑ 6.0 6.1 6.2 "Measles vaccines: WHO position paper – April 2017". Wkly. Epidemiol. Rec. 92 (17): 205–27. 2017. PMID 28459148. 
  7. ↑ Kinney, Rebecca (2 May 2017). "Core Concepts - Immunizations in Adults - Basic HIV Primary Care - National HIV CurriculumImmunizations in Adults". https://www.hiv.uw.edu/go/basic-primary-care/immunizations/core-concept/all. 
  8. ↑ "Measles, mumps, and rubella--vaccine use and strategies for elimination of measles, rubella, and congenital rubella syndrome and control of mumps: recommendations of the Advisory Committee on Immunization Practices (ACIP)". MMWR Recomm Rep 47 (RR-8): 1–57. 22 May 1998. PMID 9639369. https://www.cdc.gov/mmwr/PDF/rr/rr4708.pdf. 
  9. ↑ "Top 10 myths about MMR, Top 10 truths about MMR". http://www.iow.nhs.uk/Downloads/Health%20Visiting_School%20Nursing/MMR%20mythsandtruths.pdf. 
  10. ↑ 10.0 10.1 10.2 10.3 10.4 "Addressing misconceptions on measles vaccination". https://ecdc.europa.eu/en/measles/prevention-and-control/addressing-misconceptions-measles. 
  11. ↑ "Measles Fact Sheet #286". https://www.who.int/mediacentre/factsheets/fs286/en/. 
  12. ↑ 12.0 12.1 12.2 12.3 "MMR (Measles, Mumps, and Rubella) Vaccine Information Statement". 6 August 2021. https://www.cdc.gov/vaccines/hcp/vis/vis-statements/mmr.html. 
  13. ↑ 13.0 13.1 13.2 13.3 13.4 13.5 13.6 Di Pietrantonj, C; Rivetti, A; Marchione, P; Debalini, MG; Demicheli, V (April 2020). "Vaccines for measles, mumps, rubella, and varicella in children.". Cochrane Database of Systematic Reviews 4: CD004407. doi:10.1002/14651858.CD004407.pub4. PMID 32309885. 
  14. ↑ "The Anti-vaccination Movement: A Regression in Modern Medicine". Cureus 10 (7): e2919. 3 July 2018. doi:10.7759/cureus.2919. PMID 30186724. 
  15. ↑ 15.0 15.1 "Vaccine Adverse Events: Separating Myth from Reality". American Family Physician 95 (12): 786–794. 15 June 2017. PMID 28671426. 
  16. ↑ 16.0 16.1 16.2 Goodson, JL; Seward, JF (December 2015). "Measles 50 Years After Use of Measles Vaccine". Infectious Disease Clinics of North America 29 (4): 725–43. doi:10.1016/j.idc.2015.08.001. PMID 26610423. 
  17. ↑ "Measles: information about the disease and vaccines Questions and Answers". http://www.immunize.org/catg.d/p4209.pdf. 
  18. ↑ 18.0 18.1 18.2 "Information Sheet Observed Rate of Vaccine Reactions, Measles, Mumps, and Rubella Vaccines". May 2014. https://www.who.int/vaccine_safety/initiative/tools/MMR_vaccine_rates_information_sheet.pdf. 
  19. ↑ "Measles, mumps, rubella (MMR): use of combined vaccine instead of single vaccines". https://www.gov.uk/government/publications/mmr-vaccine-dispelling-myths/measles-mumps-rubella-mmr-maintaining-uptake-of-vaccine. 
  20. ↑ Babbott FL Jr; Gordon JE (1954). "Modern measles". Am J Med Sci 228 (3): 334–61. doi:10.1097/00000441-195409000-00013. PMID 13197385. 
  21. ↑ "Summary of notifiable diseases, United States, 1993". MMWR Morb. Mortal. Wkly. Rep. 42 (53): i-xvii; 1–73. October 1994. PMID 9247368. https://www.cdc.gov/mmwr/PDF/wk/mm4253.pdf. 
  22. ↑ "Summary of Notifiable Diseases --- United States, 2007". MMWR Morb. Mortal. Wkly. Rep. 56 (53). July 2009. https://www.cdc.gov/mmwr/pdf/wk/mm5653.pdf. 
  23. ↑ Epidemiology and Prevention of Vaccine-Preventable Diseases (13th ed.). Washington D.C.: U.S. Centers for Disease Control and Prevention (CDC). 2015. ISBN 978-0990449119. https://www.cdc.gov/vaccines/pubs/pinkbook/index.html. 
  24. ↑ "Health impact of measles vaccination in the United States". Pediatrics 76 (4): 524–32. 1985. PMID 3931045. 
  25. ↑ "Progress in reducing global measles deaths, 1999–2004". MMWR Morb. Mortal. Wkly. Rep. 55 (9): 247–9. March 2006. PMID 16528234. https://www.cdc.gov/mmwr/pdf/wk/mm5509.pdf. 
  26. ↑ "Measles Fact Sheet #286". https://www.who.int/mediacentre/factsheets/fs286/en/. 
  27. ↑ 27.0 27.1 "Implications of a 2005 measles outbreak in Indiana for sustained elimination of measles in the United States". N Engl J Med 355 (5): 447–55. 2006. doi:10.1056/NEJMoa060775. PMID 16885548. https://semanticscholar.org/paper/9b464d9d3d2dd10d3590a905e7db409843946a12. 
  28. ↑ "Measles—United States, 2005". MMWR Morb. Mortal. Wkly. Rep. 55 (50): 1348–51. December 2006. PMID 17183226. https://www.cdc.gov/mmwr/pdf/wk/mm5550.pdf. 
  29. ↑ "Measles Outbreak — Minnesota April–May 2017". MMWR Morb. Mortal. Wkly. Rep. 66 (27): 713–717. July 2017. doi:10.15585/mmwr.mm6627a1. ISSN 0149-2195. PMID 28704350. PMC 5687591. https://www.cdc.gov/mmwr/volumes/66/wr/pdfs/mm6627.pdf. 
  30. ↑ "Rubella vaccine information". National Network for Immunization Information. 2006-09-25. http://www.immunizationinfo.org/vaccineInfo/vaccine_detail.cfv?id=24. 
  31. ↑ Jequier, Anne M. (2000). Male infertility: a guide for the clinician. Malden, MA: Blackwell Publishing. p. 118. ISBN 978-0-632-05129-8. https://books.google.com/books?id=ULWh1Wc1nKMC. 
  32. ↑ 32.0 32.1 "Increasing coverage and efficiency of measles, mumps, and rubella vaccine and introducing universal varicella vaccination in Europe: a role for the combined vaccine". Pediatr Infect Dis J 26 (7): 632–8. 2007. doi:10.1097/INF.0b013e3180616c8f. PMID 17596807. 
  33. ↑ "MMR vaccine questions and answers". Centers for Disease Control and Prevention (CDC). 2004. https://www.cdc.gov/vaccines/vpd-vac/combo-vaccines/mmr/faqs-mmr-hcp.htm. 
  34. ↑ "10-minute consultation: MMR immunisation". BMJ 323 (7303): 32. 2001. doi:10.1136/bmj.323.7303.32. PMID 11440943. 
  35. ↑ "Acute Arthritis Complicating Rubella Vaccination". Arthritis & Rheumatism 14 (1): 19–26. 1971. doi:10.1002/art.1780140104. PMID 5100638. https://deepblue.lib.umich.edu/bitstream/2027.42/37715/1/1780140104_ftp.pdf. 
  36. ↑ 36.0 36.1 Schattner A (2005). "Consequence or coincidence? The occurrence, pathogenesis and significance of autoimmune manifestations after viral vaccines". Vaccine 23 (30): 3876–86. doi:10.1016/j.vaccine.2005.03.005. PMID 15917108. 
  37. ↑ "MMR immunisation. True anaphylaxis to MMR vaccine is extremely rare". BMJ 323 (7317): 869. 2001. doi:10.1136/bmj.323.7317.869a. PMID 11683165. 
  38. ↑ "Egg allergy and MMR vaccination". Br J Gen Pract 53 (495): 801–2. October 2003. PMID 14601358. PMC 1314715. http://openurl.ingenta.com/content/nlm?genre=article&issn=0960-1643&volume=53&issue=495&spage=801&aulast=Fox. 
  39. ↑ "Approval for label change". https://www.fda.gov/BiologicsBloodVaccines/Vaccines/ApprovedProducts/ucm394905.htm. 
  40. ↑ Medicine, Institute of; Practice, Board on Population Health Public Health; Vaccines, Committee to Review Adverse Effects of; Ford, A; Rusch, E; Clayton, E. W (26 March 2012). Adverse Effects of Vaccines. doi:10.17226/13164. ISBN 978-0-309-21435-3. https://www.nap.edu/read/13164/chapter/6#132. 
  41. ↑ Institute of Medicine (1994). "Measles and mumps vaccines". Adverse Events Associated with Childhood Vaccines: Evidence Bearing on Causality. National Academy Press. ISBN 978-0-309-07496-4. http://books.nap.edu/openbook.php?record_id=2138&page=131. 
  42. ↑ 42.0 42.1 "Withdrawal of a mumps vaccine". Eur J Pediatr 153 (6): 467–8. 1994. doi:10.1007/BF01983415. PMID 8088305. 
  43. ↑ "Commentary: Ongoing debate over the safety of the different mumps vaccine strains impacts mumps disease control". Int J Epidemiol 31 (5): 983–4. 2002. doi:10.1093/ije/31.5.983. PMID 12435772. 
  44. ↑ "Do childhood vaccines cause thrombocytopenia?". Paediatr Child Health 14 (1): 31–2. January 2009. doi:10.1093/pch/14.1.31. PMID 19436461. 
  45. ↑ Black, C., Kaye, J. A. and Jick, H. (2003). "MMR vaccine and idiopathic thrombocytopaenic purpura". British Journal of Clinical Pharmacology 55 (1): 107–111. doi:10.1046/j.1365-2125.2003.01790.x. PMID 12534647. 
  46. ↑ Wakefield A, Murch S, Anthony A (1998). "Ileal-lymphoid-nodular hyperplasia, non-specific colitis, and pervasive developmental disorder in children". Lancet 351 (9103): 637–41. doi:10.1016/S0140-6736(97)11096-0. PMID 9500320. http://briandeer.com/mmr/lancet-paper.htm. Retrieved 2007-09-05.  (Retracted)
  47. ↑ Cassandra Jardine (29 Jan 2010). "GMC brands Dr Andrew Wakefield 'dishonest, irresponsible and callous'". The Telegraph (London). https://www.telegraph.co.uk/news/health/7095145/GMC-brands-Dr-Andrew-Wakefield-dishonest-irresponsible-and-callous.html. 
  48. ↑ The Editors Of The Lancet (February 2010). "Retraction—Ileal-lymphoid-nodular hyperplasia, non-specific colitis, and pervasive developmental disorder in children". Lancet 375 (9713): 445. doi:10.1016/S0140-6736(10)60175-4. PMID 20137807. 
  49. ↑ "General Medical Council, Fitness to Practise Panel Hearing, 24 May 2010, Andrew Wakefield, Determination of Serious Professional Misconduct". General Medical Council. http://www.gmc-uk.org/Wakefield_SPM_and_SANCTION.pdf_32595267.pdf. 
  50. ↑ Meikle, James; Boseley, Sarah (24 May 2010). "MMR row doctor Andrew Wakefield struck off register". The Guardian (London). https://www.theguardian.com/society/2010/may/24/mmr-doctor-andrew-wakefield-struck-off. 
  51. ↑ "Wakefield's article linking MMR vaccine and autism was fraudulent". BMJ 342 (jan05 1; c7452): c7452. 2011. doi:10.1136/bmj.c7452. PMID 21209060. https://semanticscholar.org/paper/9766637ea6e30ff6feea94379372f0f80f36ac56. 
  52. ↑ 52.0 52.1 National Health Service (2004). "MMR: myths and truths". http://www.mmrthefacts.nhs.uk/basics/truths.php. 
  53. ↑ "Measles, mumps, and rubella (MMR) vaccine". Centers for Disease Control and Prevention. 2008-08-22. http://cdc.gov/vaccinesafety/concerns/mmr_autism_factsheet.htm. 
  54. ↑ Immunization Safety Review: Vaccines and Autism . From the Institute of Medicine of the National Academy of Sciences. Report dated May 17, 2004; accessed June 13, 2007.
  55. ↑ MMR Fact Sheet , from the United Kingdom National Health Service. Accessed June 13, 2007.
  56. ↑ MMR vs three separate vaccines:
  57. ↑ "Doctors issue plea over MMR jab". BBC News. 2006-06-26. http://news.bbc.co.uk/2/hi/health/5118166.stm. 
  58. ↑ Thomas J (2010). "Paranoia strikes deep: MMR vaccine and autism". Psychiatric Times 27 (3): 1–6. http://www.searchmedica.com/resource.html?rurl=http://www.psychiatrictimes.com/display/article/10168/1531916. 
  59. ↑ "No effect of MMR withdrawal on the incidence of autism: a total population study". J Child Psychol Psychiatry 46 (6): 572–9. 2005. doi:10.1111/j.1469-7610.2005.01425.x. PMID 15877763. 
  60. ↑ "Human fibroblasts infected with rubella virus produce a growth inhibitor". Science 156 (3775): 659–61. 1967. doi:10.1126/science.156.3775.659. PMID 6023662. Bibcode: 1967Sci...156..659P. 
  61. ↑ "The serial cultivation of human diploid cell strains". Exp. Cell Res. 25 (3): 585–621. 1967. doi:10.1016/0014-4827(61)90192-6. PMID 13905658. 
  62. ↑ "Attenuvax Product Sheet". Merck & Co. 2006. p. 1. http://www.merck.com/product/usa/pi_circulars/a/attenuvax/attenuvax_pi.pdf. 
  63. ↑ Merck Co. (2002). "MUMPSVAX (Mumps Virus Vaccine Live) Jeryl Lynn Strain". Merck Co.. http://www.merck.com/product/usa/pi_circulars/m/mumpsvax/mumpsvax_pi.pdf. 
  64. ↑ "Experiences with Jeryl Lynn strain live attenuated mumps virus vaccine in a pediatric outpatient clinic". Pediatrics 40 (5): 798–803. 1967. PMID 6075651. 
  65. ↑ "About the Vaccine - MMR and MMRV Vaccine Composition and Dosage". Centers for Disease Control and Prevention (CDC). 2021-01-26. https://www.cdc.gov/vaccines/vpd/mmr/hcp/about.html. 
  66. ↑ Reef, Susan E.; Plotkin, Stanley A. (2018). "Rubella Vaccines". Plotkin's Vaccines. pp. 970–1000.e18. doi:10.1016/B978-0-323-35761-6.00052-3. ISBN 9780323357616. 
  67. ↑ 67.0 67.1 67.2 Böröcz, K.; Csizmadia, Z.; Markovics, Á.; Farkas, N.; Najbauer, J.; Berki, T.; Németh, P. (2020). "Application of a fast and cost-effective 'three-in-one' MMR ELISA as a tool for surveying anti-MMR humoral immunity: The Hungarian experience". Epidemiology and Infection 148: e17. doi:10.1017/S0950268819002280. PMID 32014073. 
  68. ↑ "Update: recommendations from the Advisory Committee on Immunization Practices (ACIP) regarding administration of combination MMRV vaccine". MMWR Morb. Mortal. Wkly. Rep. 57 (10): 258–60. March 2008. PMID 18340332. https://www.cdc.gov/mmwr/PDF/wk/mm5710.pdf. 
  69. ↑ "Febrile seizures and measles-mumps-rubella-varicella (MMRV) vaccine: what do primary care physicians think?". Vaccine 30 (48): 6731–3. Nov 2012. doi:10.1016/j.vaccine.2012.08.075. PMID 22975026. 
  70. ↑ Pager, Tyler (9 April 2019). "'Monkey, Rat and Pig DNA': How Misinformation Is Driving the Measles Outbreak Among Ultra-Orthodox Jews". The New York Times. https://www.nytimes.com/2019/04/09/nyregion/jews-measles-vaccination.html. 
  71. ↑ "Vaccines and porcine gelatine". Public Health England. August 2015. https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachment_data/file/751199/Vaccines_porcine_gelatine.pdf. 

Further reading

External links



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