Biology:Α-N-Acetylglucosaminidase

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Short description: Class of enzymes
α-N-acetylglucosaminidase
Human N-acetyl-alpha-glucosaminidase PDB=4XWH.png
Human α-N-acetylglucosaminidase coloured by domain.[1] PDB: 4XWH
Identifiers
SymbolNAGLU
NCBI gene4669
HGNC7632
OMIM609701
RefSeqNM_000263
UniProtP54802
Other data
EC number3.2.1.50
LocusChr. 17 q11-q21

The enzyme α-N-acetylglucosaminidase (EC 3.2.1.50, α-acetylglucosaminidase, N-acetyl-α-D-glucosaminidase, N-acetyl-α-glucosaminidase, α-D-2-acetamido-2-deoxyglucosidase) is a protein associated with Sanfilippo syndrome, with systematic name α-N-acetyl-D-glucosaminide N-acetylglucosaminohydrolase.[2][3][4][5] It catalyses the hydrolysis of terminal non-reducing N-acetyl-D-glucosamine residues in N-acetyl-α-D-glucosaminides, and also UDP-N-acetylglucosamine.

References

  1. Birrane, Gabriel; Dassier, Anne-Laure; Romashko, Alla; Lundberg, Dianna; Holmes, Kevin; Cottle, Thomas; Norton, Angela W.; Zhang, Bohong et al. (2019). "Structural characterization of the α-N-acetylglucosaminidase, a key enzyme in the pathogenesis of Sanfilippo syndrome B" (in en). Journal of Structural Biology 205 (3): 65–71. doi:10.1016/j.jsb.2019.02.005. PMID 30802506. 
  2. "Human α-N-acetylglucosaminidase. 1. Purification and properties". European Journal of Biochemistry 80 (2): 523–533. November 1977. doi:10.1111/j.1432-1033.1977.tb11908.x. PMID 411658. 
  3. "Human α-N-acetylglucosaminidase. 2. Activity towards natural substrates and multiple recognition forms". European Journal of Biochemistry 80 (2): 535–542. November 1977. doi:10.1111/j.1432-1033.1977.tb11909.x. PMID 923593. 
  4. "Mammalian α-acetylglucosaminidase. Enzymic properties, tissue distribution, and intracellular localization". Biochemistry 6 (1): 207–214. January 1967. doi:10.1021/bi00853a033. PMID 4291567. 
  5. "Separation of N-acetyl-α-glucosaminidase and N-acetyl-α-galactosaminidase from ox spleen. Cleavage of the O-glycosidic linkage between carbohydrate and polypeptide in ovine and bovine submaxillary glycoprotein by N-acetyl-α-galactosaminidase". European Journal of Biochemistry 10 (3): 445–449. October 1969. doi:10.1111/j.1432-1033.1969.tb00709.x. PMID 5348072. 

External links