Biology:Blood group B branched chain alpha-1,3-galactosidase
From HandWiki
Short description: Class of enzymes
| Heparanase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 3.2.1.166 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Heparanase (EC 3.2.1.166, Hpa1 heparanase, Hpa1, heparanase 1, heparanase-1, C1A heparanase, HPSE) is an enzyme with systematic name heparan sulfate N-sulfo-D-glucosamine endoglucanase.[1][2][3][4][5][6][7][8][9] This enzyme catalyses the following chemical reaction
- endohydrolysis of (1->4)-beta-D-glycosidic bonds of heparan sulfate chains in heparan sulfate proteoglycan
Heparanase cleaves the linkage between a glucuronic acid unit and an N-sulfo glucosamine unit carrying either a 3-O-sulfo or a 6-O-sulfo group.
See also
References
- ↑ "Heparanases: endoglycosidases that degrade heparan sulfate proteoglycans". Glycobiology 11 (6): 91R–98R. June 2001. doi:10.1093/glycob/11.6.91r. PMID 11445547.
- ↑ "Unraveling the specificity of heparanase utilizing synthetic substrates". The Journal of Biological Chemistry 285 (19): 14504–13. May 2010. doi:10.1074/jbc.M110.104166. PMID 20181948.
- ↑ "Substrate specificity of heparanases from human hepatoma and platelets". The Journal of Biological Chemistry 273 (30): 18770–7. July 1998. doi:10.1074/jbc.273.30.18770. PMID 9668050.
- ↑ "Structural recognition by recombinant human heparanase that plays critical roles in tumor metastasis. Hierarchical sulfate groups with different effects and the essential target disulfated trisaccharide sequence". The Journal of Biological Chemistry 277 (45): 42488–95. November 2002. doi:10.1074/jbc.M206510200. PMID 12213822.
- ↑ "Mammalian heparanase: what is the message?". Journal of Cellular and Molecular Medicine 11 (3): 427–52. 2007. doi:10.1111/j.1582-4934.2007.00039.x. PMID 17635638.
- ↑ "Processing of macromolecular heparin by heparanase". The Journal of Biological Chemistry 278 (37): 35152–8. September 2003. doi:10.1074/jbc.M300925200. PMID 12837765.
- ↑ "Human heparanase. Purification, characterization, cloning, and expression". The Journal of Biological Chemistry 274 (34): 24153–60. August 1999. doi:10.1074/jbc.274.34.24153. PMID 10446189.
- ↑ "Cloning, expression, and purification of mouse heparanase". Protein Expression and Purification 26 (3): 425–31. December 2002. doi:10.1016/s1046-5928(02)00558-2. PMID 12460766.
- ↑ "Development of a colorimetric assay for heparanase activity suitable for kinetic analysis and inhibitor screening". Analytical Biochemistry 396 (1): 112–6. January 2010. doi:10.1016/j.ab.2009.09.007. PMID 19748475. https://eprints.qut.edu.au/27855/2/27855a.pdf.
External links
- Heparanase at the US National Library of Medicine Medical Subject Headings (MeSH)
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