Biology:CYP3A43
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Cytochrome P450 3A43 is a protein that in humans is encoded by the CYP3A43 gene.[1][2][3]
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This enzyme has a low level of testosterone hydroxylase activity. Although it bears homology to some drug-metabolizing cytochrome P450s, it is unknown whether the enzyme is also involved in xenobiotic metabolism. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Alternate splicing of this gene results in three transcript variants encoding different isoforms.[3]
References
- ↑ "cDNA cloning and initial characterization of CYP3A43, a novel human cytochrome P450". Mol Pharmacol 59 (2): 386–92. Feb 2001. doi:10.1124/mol.59.2.386. PMID 11160876.
- ↑ "Genomic organization of the human CYP3A locus: identification of a new, inducible CYP3A gene". Pharmacogenetics 11 (2): 111–21. Mar 2001. doi:10.1097/00008571-200103000-00002. PMID 11266076.
- ↑ 3.0 3.1 "Entrez Gene: CYP3A43 cytochrome P450, family 3, subfamily A, polypeptide 43". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=64816.
External links
- Human CYP3A43 genome location and CYP3A43 gene details page in the UCSC Genome Browser.
Further reading
- "Molecular genetics of the human cytochrome P450 monooxygenase superfamily". Xenobiotica 28 (12): 1129–65. 1999. doi:10.1080/004982598238868. PMID 9890157.
- "The human cytochrome P450 3A locus. Gene evolution by capture of downstream exons". Gene 260 (1–2): 13–23. 2001. doi:10.1016/S0378-1119(00)00470-4. PMID 11137287.
- "Cloning and tissue distribution of a novel human cytochrome p450 of the CYP3A subfamily, CYP3A43". Biochem. Biophys. Res. Commun. 281 (5): 1349–55. 2001. doi:10.1006/bbrc.2001.4505. PMID 11243885.
- "Intergenic mRNA molecules resulting from trans-splicing". J. Biol. Chem. 277 (8): 5882–90. 2002. doi:10.1074/jbc.M109175200. PMID 11726664.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "The DNA sequence of human chromosome 7". Nature 424 (6945): 157–64. 2003. doi:10.1038/nature01782. PMID 12853948. Bibcode: 2003Natur.424..157H.
- "First report of a genetic polymorphism of the cytochrome P450 3A43 (CYP3A43) gene: identification of a loss-of-function variant". Hum. Mutat. 23 (1): 101. 2004. doi:10.1002/humu.9211. PMID 14695544.
- "An unappreciated role for RNA surveillance". Genome Biol. 5 (2): R8. 2005. doi:10.1186/gb-2004-5-2-r8. PMID 14759258.
- "CYP3A43 Pro(340)Ala polymorphism and prostate cancer risk in African Americans and Caucasians". Cancer Epidemiol. Biomarkers Prev. 14 (5): 1257–61. 2005. doi:10.1158/1055-9965.EPI-04-0534. PMID 15894682.
- "Sequence diversity and haplotype structure at the human CYP3A cluster". Pharmacogenomics J. 6 (2): 105–14. 2006. doi:10.1038/sj.tpj.6500347. PMID 16314882.
- "Analysis of restriction fragment length polymorphism of cytochrome P450 3A43 gene and evaluation of the incidence of CYP3A43*1B allele in europeoid residents of West Siberia". Bull. Exp. Biol. Med. 140 (6): 726–8. 2006. doi:10.1007/s10517-006-0067-6. PMID 16848237.
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