Biology:CYP4A22
 Generic protein structure example |
CYP4A22 (cytochrome P450, family 4, subfamily A, polypeptide 22) also known as fatty acid omega-hydroxylase is a protein which in humans is encoded by the CYP4A22 gene.[1]
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This gene is part of a cluster of cytochrome P450 genes on chromosome 1p33.[2]
CYP4A22 was once considered, along with CYP4A11, CYP4F2, and CYP4F3, as active in metabolizing arachidonic acid to 20-hydroxyeicosatetraenoic acid (20-HETE) by an omega oxidation reaction with the predominant 20-HETE-synthesizing enzymes in humans being CYP4F2 followed by CYP4A11; 20-HETE regulates blood flow, vascularization, blood pressure, and kidney tubule absorption of ions in rodents and possibly humans.[3] However, human CYP4A22 is expressed at very low levels in few tissues and may not be a functional enzyme in regard to the metabolism of arachidonic acid to 20-HETE.[4][5]
References
- ↑ "Genetic polymorphisms and haplotype structures of the CYP4A22 gene in a Japanese population". Mutation Research 599 (1–2): 98–104. Jul 2006. doi:10.1016/j.mrfmmm.2006.02.008. PMID 16806293.
- ↑ Template:NCBI RefSeq
- ↑ "Vascular actions of 20-HETE". Prostaglandins & Other Lipid Mediators 120: 9–16. Jul 2015. doi:10.1016/j.prostaglandins.2015.03.002. PMID 25813407.
- ↑ "Functional variant of CYP4A11 20-hydroxyeicosatetraenoic acid synthase is associated with essential hypertension". Circulation 111 (1): 63–9. Jan 2005. doi:10.1161/01.CIR.0000151309.82473.59. PMID 15611369.
- ↑ "CYP4 enzymes as potential drug targets: focus on enzyme multiplicity, inducers and inhibitors, and therapeutic modulation of 20-hydroxyeicosatetraenoic acid (20-HETE) synthase and fatty acid ω-hydroxylase activities". Current Topics in Medicinal Chemistry 13 (12): 1429–40. 2013. doi:10.2174/15680266113139990110. PMID 23688133.
External links
- Human CYP4A22 genome location and CYP4A22 gene details page in the UCSC Genome Browser.
Further reading
- "Characterization of the CYP4A11 gene, a second CYP4A gene in humans". Archives of Biochemistry and Biophysics 409 (1): 221–7. Jan 2003. doi:10.1016/S0003-9861(02)00545-3. PMID 12464262.
- "Functional variant of CYP4A11 20-hydroxyeicosatetraenoic acid synthase is associated with essential hypertension". Circulation 111 (1): 63–9. Jan 2005. doi:10.1161/01.CIR.0000151309.82473.59. PMID 15611369.
- "Comparison of cytochrome P450 (CYP) genes from the mouse and human genomes, including nomenclature recommendations for genes, pseudogenes and alternative-splice variants". Pharmacogenetics 14 (1): 1–18. Jan 2004. doi:10.1097/00008571-200401000-00001. PMID 15128046.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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