Biology:Cytochrome P450 eryF
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Short description: Enzyme
| Cytochrome P450 eryF | |||||||
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| Organism | |||||||
| Symbol | eryF | ||||||
| Alt. symbols | CYP107A1 | ||||||
| UniProt | Q00441 | ||||||
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| EC number | 1.14.15.35 | ||||||
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6-deoxyerythronolide B hydroxylase is an Actinomycetota Cytochrome P450 enzyme originally from Saccharopolyspora erythraea, catalyzes the 6S-hydroxylate of 6-deoxyerythronolide B (6-DEB) to erythronolide B (EB) which is the first step of biosynthesis of the macrolide antibiotic erythromycin.[1][2] This bacterial enzyme belongs to CYP family CYP107, with the CYP Symbol CYP107A1.[3][4]
References
- ↑ "An erythromycin derivative produced by targeted gene disruption in Saccharopolyspora erythraea". Science 252 (5002): 114–7. April 1991. doi:10.1126/science.2011746. PMID 2011746. Bibcode: 1991Sci...252..114W.
- ↑ "Characterization of Saccharopolyspora erythraea cytochrome P-450 genes and enzymes, including 6-deoxyerythronolide B hydroxylase". Journal of Bacteriology 174 (3): 725–35. February 1992. doi:10.1128/jb.174.3.725-735.1992. PMID 1732208.
- ↑ "Structure of cytochrome P450eryF involved in erythromycin biosynthesis". Nature Structural Biology 2 (2): 144–53. February 1995. doi:10.1038/nsb0295-144. PMID 7749919.
- ↑ "Oxidation and electronic state dependence of proton transfer in the enzymatic cycle of cytochrome P450eryF". Journal of Inorganic Biochemistry 91 (4): 568–85. September 2002. doi:10.1016/s0162-0134(02)00477-4. PMID 12237223.
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