Biology:CYP3A7
 Generic protein structure example |
CYP3A7 is an enzyme belonging to the cytochrome P450 family. It is 503 amino acids in size and shares 87% of its sequence with CYP3A4. It carries out a similar role in fetuses that CYP3A4 serves in adults.[1] The gene location is 7q22.1.[2]
The CYP3A group of enzymes are the most abundantly expressed members of the cytochrome P450 family in liver. They are responsible for the metabolism of more than 50% of all clinical pharmaceuticals.[3]
The CYP3A7 enzyme hydroxylates testosterone and dehydroepiandrosterone 3-sulphate, which is involved in the formation of estriol during pregnancy. The CYP3A7 gene is part of a cluster of related genes on chromosome 7q21.1. Naturally-occurring readthrough transcription occurs between this gene and the downstream CYP3A51P pseudogene.[4]
Notable alleles
The CYP3A7*1C allele is associated with poor outcomes in some cancer patients, possibly because of the effect of the enzyme on some chemotherapy agents.[5]
References
- ↑ "Molecular cloning and sequence analysis of cDNA containing the entire coding region for human fetal liver cytochrome P-450". J. Biochem. 105 (2): 161–3. February 1989. doi:10.1093/oxfordjournals.jbchem.a122632. PMID 2722762.
- ↑ "Cytochrome P450, Subfamily IIIA, Polypeptide 7". OMIM. http://www.omim.org/entry/605340. Retrieved March 14, 2013.
- ↑ "Two linked mutations in transcriptional regulatory elements of the CYP3A5 gene constitute the major genetic determinant of polymorphic activity in humans". Pharmacogenetics 10 (5): 415–24. July 2000. doi:10.1097/00008571-200007000-00005. PMID 10898111.
- ↑ Template:NCBI RefSeq
- ↑ "CYP3A7*1C Allele Associated With Poor Outcomes in CLL, Breast, and Lung Cancer". http://www.oncotherapynetwork.com/lung-cancer-targets/cyp3a71c-allele-associated-poor-outcomes-cll-breast-and-lung-cancer.
External links
- CYP3A7 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
- Human CYP3A7 genome location and CYP3A7 gene details page in the UCSC Genome Browser.
 |  |
