Biology:Daf-9
From HandWiki
| Cytochrome P450 daf-9 | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Organism | |||||||
| Symbol | daf-9 | ||||||
| Alt. symbols | CYP22A1 | ||||||
| Entrez | 180889 | ||||||
| RefSeq (mRNA) | NM_001029732.2 | ||||||
| RefSeq (Prot) | NP_001024903.1 | ||||||
| UniProt | H2KYS3 | ||||||
| Other data | |||||||
| Chromosome | X: 6.2 - 6.2 Mb | ||||||
| |||||||
The daf-9 gene encodes a cytochrome p450 enzyme that catalyses the generation of dafachronic acid (a steroid hormone) in the worm Caenorhabditis elegans,[1][2] with the CYP Symbol CYP22A1 (Cytochrome P450, family 22, member A1). After generation, dafachronic acid will bind its nuclear receptor Daf-12, whose genetic mutation has been implicated by Cynthia Kenyon and colleagues as related to the formation of Dauer larva.[3]
References
- ↑ "DAF-9, a cytochrome P450 regulating C. elegans larval development and adult longevity". Development 129 (1): 221–31. 2002. doi:10.1242/dev.129.1.221. PMID 11782415.
- ↑ "Identification of Ligands for DAF-12 that Govern Dauer Formation and Reproduction in C. elegans". Cell 124 (6): 1209-1223. 2006. doi:10.1016/j.cell.2006.01.037. PMID 16529801.
- ↑ "A C. elegans mutant that lives twice as long as wild type". Nature 366 (6454): 461–464. 1993. doi:10.1038/366461a0. PMID 8247153. Bibcode: 1993Natur.366..461K.
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