Biology:Endoglycosylceramidase
From HandWiki
| endoglycosylceramidase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 3.2.1.123 | ||||||||
| CAS number | 105503-61-5 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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The enzyme endoglycosylceramidase (EC 3.2.1.123) catalyzes the following chemical reaction:
- oligoglycosylglucosylceramide + H2O [math]\displaystyle{ \rightleftharpoons }[/math] ceramide + oligoglycosylglucose
This enzyme belongs to the family of hydrolases, specifically those glycosidases that hydrolyse O- and S-glycosyl compounds. The systematic name is oligoglycosylglucosylceramide glycohydrolase. Other names in common use include endoglycoceramidase, EGCase, and glycosyl-N-acetyl-sphingosine 1,1-β-D-glucanohydrolase.
Structural studies
As of late 2007, 6 structures have been solved for this class of enzymes, with PDB accession codes 2OSW, 2OSX, 2OSY, 2OYK, 2OYL, and 2OYM.
References
- "A novel glycosphingolipid-degrading enzyme cleaves the linkage between the oligosaccharide and ceramide of neutral and acidic glycosphingolipids". J. Biol. Chem. 261 (30): 14278–82. 1986. PMID 3771534.
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