Biology:Fosfluconazole
From HandWiki
Short description: Chemical compound
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| AHFS/Drugs.com | International Drug Names |
| Routes of administration | IV |
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| Formula | C13H13F2N6O4P |
| Molar mass | 386.256 g·mol−1 |
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Fosfluconazole (INN) is a water-soluble phosphate prodrug of fluconazole[1] — a triazole antifungal drug used in the treatment and prevention of superficial and systemic fungal infections.[2]
The phosphate ester bond is hydrolyzed by the action of a phosphatase — an enzyme that removes a phosphate group from its substrate by hydrolyzing phosphoric acid monoesters into a phosphate ion and a molecule with a free hydroxyl group (dephosphorylation).[3]
References
- ↑ "The Discovery and Process Development of a Commercial Route to the Water Soluble Prodrug, Fosfluconazole". Organic Process Research & Development 6 (2): 109–112. 2002. doi:10.1021/op010064+. ISSN 1083-6160.
- ↑ "Fosfluconazole for antifungal prophylaxis in very low birth weight infants". International Journal of Pediatrics 2009 (2009): 274768. 2009-05-25. doi:10.1155/2009/274768. PMID 19946419.
- ↑ "The enzymatic hydrolysis of the phosphate ester bond in some thionucleotides". Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis 561 (1): 223–231. January 1979. doi:10.1016/0005-2787(79)90505-7. PMID 84687.
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