Biology:Isoconazole
From HandWiki
Isoconazole is an azole antifungal drug and could inhibit gram positive bacteria.[1][2] For foot and vaginal infections, isoconazole has a similar effectiveness to clotrimazole.[3][4] Isoconazole nitrate may be used in combination with corticosteroid diflucortolone to increase its bioavailability.[1]
It was patented in 1968 and approved for medical use in 1979.[5]
Isoconazole is also known to bind to tubulin and inhibit its polymerization. [6]
References
- ↑ 1.0 1.1 "Isoconazole nitrate: a unique broad-spectrum antimicrobial azole effective in the treatment of dermatomycoses, both as monotherapy and in combination with corticosteroids". Mycoses 56 (Suppl 1): 3–15. May 2013. doi:10.1111/myc.12054. PMID 23574019.
- ↑ "Isoconazole". The Merck Index (12th ed.). Taylor & Francis. 1996. p. 5176. ISBN 0-911910-12-3.
- ↑ "Isoconazole nitrate versus clotrimazole in foot and nail infections due to Hendersonula toruloidea, Scytalidium hyalinum and dermatophytes". Mycoses 35 (11–12): 357–361. 1992. doi:10.1111/j.1439-0507.1992.tb00894.x. PMID 1302811.
- ↑ "Single dose treatment of vaginal candidosis: comparison of clotrimazole and isoconazole". The British Journal of Venereal Diseases 60 (1): 42–44. February 1984. doi:10.1136/sti.60.1.42. PMID 6365236.
- ↑ (in en) Analogue-based Drug Discovery. John Wiley & Sons. 2006. p. 502. ISBN 9783527607495. https://books.google.com/books?id=FjKfqkaKkAAC&pg=PA502.
- ↑ "NanoDSF Screening for Anti-tubulin Agents Uncovers New Structure–Activity Insights". Journal of Medicinal Chemistry. 2025. doi:10.1021/acs.jmedchem.5c01008.
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