Biology:GRIK5
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Glutamate receptor, ionotropic kainate 5 is a protein that in humans is encoded by the GRIK5 gene.[1][2]
Function
This gene encodes a protein that belongs to the glutamate-gated ionic channel family. Glutamate functions as the major excitatory neurotransmitter in the central nervous system through activation of ligand-gated ion channels and G protein-coupled membrane receptors. The protein encoded by this gene forms functional heteromeric kainate-preferring ionic channels with the subunits encoded by related gene family members.[2]
Interactions
GRIK5 has been shown to interact with DLG4[3][4] and GRIK2.[5][6]
See also
References
- ↑ "The genes encoding the glutamate receptor subunits KA1 and KA2 (GRIK4 and GRIK5) are located on separate chromosomes in human, mouse, and rat". Proc Natl Acad Sci U S A 91 (25): 11849–53. January 1995. doi:10.1073/pnas.91.25.11849. PMID 7527545. Bibcode: 1994PNAS...9111849S.
- ↑ 2.0 2.1 "Entrez Gene: GRIK5 glutamate receptor, ionotropic, kainate 5". https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=2901.
- ↑ "Molecular mechanisms regulating the differential association of kainate receptor subunits with SAP90/PSD-95 and SAP97". J. Biol. Chem. 276 (19): 16092–9. May 2001. doi:10.1074/jbc.M100643200. PMID 11279111.
- ↑ "SAP90 binds and clusters kainate receptors causing incomplete desensitization". Neuron 21 (4): 727–39. October 1998. doi:10.1016/S0896-6273(00)80590-5. PMID 9808460.
- ↑ "Biochemical and assembly properties of GluR6 and KA2, two members of the kainate receptor family, determined with subunit-specific antibodies". J. Biol. Chem. 269 (2): 1332–9. January 1994. doi:10.1016/S0021-9258(17)42262-9. PMID 8288598.
- ↑ "Expression and heteromeric interactions of non-N-methyl-D-aspartate glutamate receptor subunits in the developing and adult cerebellum". Neuroscience 82 (2): 485–97. January 1998. doi:10.1016/S0306-4522(97)00296-0. PMID 9466455.
Further reading
- "Molecular structure and pharmacological characterization of humEAA2, a novel human kainate receptor subunit.". Mol. Pharmacol. 42 (1): 10–5. 1992. doi:10.1016/S0026-895X(25)08835-2. PMID 1321949.
- "Kainate/AMPA receptors expressed on human fetal astrocytes in long-term culture.". J. Neurosci. Res. 47 (3): 311–21. 1997. doi:10.1002/(SICI)1097-4547(19970201)47:3<311::AID-JNR9>3.0.CO;2-L. PMID 9039653.
- "Distribution of kainate receptor subunit mRNAs in human hippocampus, neocortex and cerebellum, and bilateral reduction of hippocampal GluR6 and KA2 transcripts in schizophrenia.". Brain Res. 751 (2): 217–31. 1997. doi:10.1016/S0006-8993(96)01404-7. PMID 9099808.
- "Expression and heteromeric interactions of non-N-methyl-D-aspartate glutamate receptor subunits in the developing and adult cerebellum.". Neuroscience 82 (2): 485–97. 1998. doi:10.1016/S0306-4522(97)00296-0. PMID 9466455.
- "SAP90 binds and clusters kainate receptors causing incomplete desensitization.". Neuron 21 (4): 727–39. 1998. doi:10.1016/S0896-6273(00)80590-5. PMID 9808460.
- "Molecular mechanisms regulating the differential association of kainate receptor subunits with SAP90/PSD-95 and SAP97.". J. Biol. Chem. 276 (19): 16092–9. 2001. doi:10.1074/jbc.M100643200. PMID 11279111.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Heteromer formation of delta2 glutamate receptors with AMPA or kainate receptors.". Brain Res. Mol. Brain Res. 110 (1): 27–37. 2003. doi:10.1016/S0169-328X(02)00561-2. PMID 12573530.
- "Trafficking and surface expression of the glutamate receptor subunit, KA2.". Biochem. Biophys. Res. Commun. 310 (1): 8–13. 2003. doi:10.1016/j.bbrc.2003.08.115. PMID 14511640. Bibcode: 2003BBRC..310....8H. https://zenodo.org/record/1258780.
- "Refined linkage to the RDP/DYT12 locus on 19q13.2 and evaluation of GRIK5 as a candidate gene.". Mov. Disord. 19 (7): 845–7. 2004. doi:10.1002/mds.20095. PMID 15254951.
External links
- GRIK5+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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