Biology:P2RX6
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
P2X purinoceptor 6 is a protein that in humans is encoded by the P2RX6 gene.[1][2][3][4]
The protein encoded by this gene belongs to the family of P2X receptors, which are ATP-gated ion channels and mediate rapid and selective permeability to cations. This gene is predominantly expressed in skeletal muscle, and regulated by p53. The encoded protein is associated with VE-cadherin at the adherens junctions of human umbilical vein endothelial cells.[4]
See also
References
- ↑ "Cloning of P2XM, a novel human P2X receptor gene regulated by p53". Cancer Res 57 (15): 3281–7. Sep 1997. PMID 9242461.
- ↑ "The DNA sequence of human chromosome 22". Nature 402 (6761): 489–95. Dec 1999. doi:10.1038/990031. PMID 10591208. Bibcode: 1999Natur.402..489D.
- ↑ "Cloning OF P2X5 and P2X6 receptors and the distribution and properties of an extended family of ATP-gated ion channels". J Neurosci 16 (8): 2495–507. Sep 1996. doi:10.1523/JNEUROSCI.16-08-02495.1996. PMID 8786426.
- ↑ 4.0 4.1 "Entrez Gene: P2RXL1 purinergic receptor P2X-like 1, orphan receptor". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9127.
Further reading
- "International union of pharmacology. XXIV. Current status of the nomenclature and properties of P2X receptors and their subunits.". Pharmacol. Rev. 53 (1): 107–18. 2001. PMID 11171941.
- "Cloning and tissue distribution of a novel P2X receptor from rat brain.". Biochem. Biophys. Res. Commun. 223 (2): 456–60. 1996. doi:10.1006/bbrc.1996.0915. PMID 8670303.
- "P2X4 and P2X6 receptors associate with VE-cadherin in human endothelial cells.". Cell. Mol. Life Sci. 59 (5): 870–81. 2002. doi:10.1007/s00018-002-8474-y. PMID 12088286.
- "Identification of the phosphotyrosine proteome from thrombin activated platelets.". Proteomics 2 (6): 642–8. 2003. doi:10.1002/1615-9861(200206)2:6<642::AID-PROT642>3.0.CO;2-I. PMID 12112843.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "A genome annotation-driven approach to cloning the human ORFeome.". Genome Biol. 5 (10): R84. 2005. doi:10.1186/gb-2004-5-10-r84. PMID 15461802.
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "Atomic force microscopy imaging demonstrates that P2X2 receptors are trimers but that P2X6 receptor subunits do not oligomerize.". J. Biol. Chem. 280 (11): 10759–65. 2005. doi:10.1074/jbc.M412265200. PMID 15657042.
- "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. 2006. doi:10.1101/gr.4039406. PMID 16344560.
External links
- P2RXL1+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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