Biology:CHRNB4

Short description: Protein-coding gene in humans

Generic protein structure example

Neuronal acetylcholine receptor subunit beta-4 is a protein that in humans is encoded by the CHRNB4 gene.

Interactive pathway map

Click on genes, proteins and metabolites below to link to respective Wikipedia articles.

[[File:

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

|{{{bSize}}}px|alt=Nicotine Activity on Chromaffin Cells edit]]

Nicotine Activity on Chromaffin Cells edit

See also

• Nicotinic acetylcholine receptor

Further reading

• "Ion-channel assembly". Trends Neurosci. 18 (6): 280–287. 1995. doi:10.1016/0166-2236(95)93915-K. PMID 7571003. 
• "Nicotinic acetylcholine receptors: from structure to brain function". Rev. Physiol. Biochem. Pharmacol.. Reviews of Physiology, Biochemistry and Pharmacology 147: 1–46. 2003. doi:10.1007/s10254-003-0005-1. ISBN 978-3-540-01365-5. PMID 12783266. 
• Tarroni P; Rubboli F; Chini B et al. (1992). "Neuronal-type nicotinic receptors in human neuroblastoma and small-cell lung carcinoma cell lines". FEBS Lett. 312 (1): 66–70. doi:10.1016/0014-5793(92)81411-E. PMID 1330682. Bibcode: 1992FEBSL.312...66T. 
• "Chromosomal localization of seven neuronal nicotinic acetylcholine receptor subunit genes in humans". Genomics 13 (4): 962–967. 1992. doi:10.1016/0888-7543(92)90008-G. PMID 1505988. 
• Raimondi E; Rubboli F; Moralli D et al. (1992). "Chromosomal localization and physical linkage of the genes encoding the human alpha 3, alpha 5, and beta 4 neuronal nicotinic receptor subunits". Genomics 12 (4): 849–50. doi:10.1016/0888-7543(92)90324-L. PMID 1572664. 
• Boulter J; O'Shea-Greenfield A; Duvoisin RM et al. (1990). "Alpha 3, alpha 5, and beta 4: three members of the rat neuronal nicotinic acetylcholine receptor-related gene family form a gene cluster". J. Biol. Chem. 265 (8): 4472–82. doi:10.1016/S0021-9258(19)39588-2. PMID 1689727. 
• "The role of the beta 4-subunit in determining the kinetic properties of rat neuronal nicotinic acetylcholine alpha 3-receptors". J. Physiol. 440: 95–112. 1992. doi:10.1113/jphysiol.1991.sp018698. PMID 1725184. 
• Elliott KJ; Ellis SB; Berckhan KJ et al. (1997). "Comparative structure of human neuronal alpha 2-alpha 7 and beta 2-beta 4 nicotinic acetylcholine receptor subunits and functional expression of the alpha 2, alpha 3, alpha 4, alpha 7, beta 2, and beta 4 subunits". J. Mol. Neurosci. 7 (3): 217–228. doi:10.1007/BF02736842. PMID 8906617. 
• Chavez-Noriega LE; Crona JH; Washburn MS et al. (1997). "Pharmacological characterization of recombinant human neuronal nicotinic acetylcholine receptors h alpha 2 beta 2, h alpha 2 beta 4, h alpha 3 beta 2, h alpha 3 beta 4, h alpha 4 beta 2, h alpha 4 beta 4 and h alpha 7 expressed in Xenopus oocytes". J. Pharmacol. Exp. Ther. 280 (1): 346–56. doi:10.1016/S0022-3565(24)36376-1. PMID 8996215. 
• "Cloning and sequence of full-length cDNAs encoding the human neuronal nicotinic acetylcholine receptor (nAChR) subunits beta3 and beta4 and expression of seven nAChR subunits in the human neuroblastoma cell line SH-SY5Y and/or IMR-32". FEBS Lett. 400 (3): 309–314. 1997. doi:10.1016/S0014-5793(96)01383-X. PMID 9009220. 
• "Expression of the alpha 7 subunit of the nicotinic acetylcholine receptor in normal and myasthenic human thymuses". Cell. Mol. Biol. (Noisy-le-grand) 43 (3): 433–42. 1997. PMID 9193799. 
• ""Orphan" alpha6 nicotinic AChR subunit can form a functional heteromeric acetylcholine receptor". Mol. Pharmacol. 51 (2): 320–7. 1997. doi:10.1124/mol.51.2.320. PMID 9203638. 
• "alpha 5 Subunit alters desensitization, pharmacology, Ca++ permeability and Ca++ modulation of human neuronal alpha 3 nicotinic receptors". J. Pharmacol. Exp. Ther. 286 (1): 311–20. 1998. doi:10.1016/S0022-3565(24)37589-5. PMID 9655874. 
• Hellström-Lindahl E; Gorbounova O; Seiger A et al. (1998). "Regional distribution of nicotinic receptors during prenatal development of human brain and spinal cord". Brain Res. Dev. Brain Res. 108 (1–2): 147–160. doi:10.1016/S0165-3806(98)00046-7. PMID 9693793. 
• Sato KZ; Fujii T; Watanabe Y et al. (1999). "Diversity of mRNA expression for muscarinic acetylcholine receptor subtypes and neuronal nicotinic acetylcholine receptor subunits in human mononuclear leukocytes and leukemic cell lines". Neurosci. Lett. 266 (1): 17–20. doi:10.1016/S0304-3940(99)00259-1. PMID 10336173. 
• "Stoichiometry of human recombinant neuronal nicotinic receptors containing the b3 subunit expressed in Xenopus oocytes". J. Physiol. 529 (3): 565–77. 2001. doi:10.1111/j.1469-7793.2000.00565.x. PMID 11118490. 
• Lev-Lehman E; Bercovich D; Xu W et al. (2001). "Characterization of the human beta4 nAChR gene and polymorphisms in CHRNA3 and CHRNB4". J. Hum. Genet. 46 (7): 362–366. doi:10.1007/PL00010921. PMID 11450844. 
• "Formation of functional alpha3beta4alpha5 human neuronal nicotinic receptors in Xenopus oocytes: a reporter mutation approach". Br. J. Pharmacol. 134 (4): 789–796. 2001. doi:10.1038/sj.bjp.0704313. PMID 11606319. 

External links

• CHRNB4+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
• Human CHRNB4 genome location and CHRNB4 gene details page in the UCSC Genome Browser.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.