Biology:GABRG3

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

GABA_A receptor-γ3, also known as GABRG3, is a protein which in humans is encoded by the GABRG3 gene.

Function

GABRG3 is a subunit of the GABA_A receptor for the neurotransmitter gamma-Aminobutyric acid (GABA).

Association with alcoholism

Genetic markers near the GABRG3 gene are statistically linked to alcoholism.

See also

• GABAA receptor

Further reading

• "The gamma-aminobutyric acid receptor gamma 3 subunit gene (GABRG3) is tightly linked to the alpha 5 subunit gene (GABRA5) on human chromosome 15q11-q13 and is transcribed in the same orientation.". Genomics 26 (2): 258–264. 1995. doi:10.1016/0888-7543(95)80209-5. PMID 7601451. 
• "gamma-Aminobutyric acidA receptors displaying association of gamma 3-subunits with beta 2/3 and different alpha-subunits exhibit unique pharmacological properties.". J. Biol. Chem. 269 (17): 12993–12998. 1994. doi:10.1016/S0021-9258(18)99974-6. PMID 8175718. 
• "Expression and pharmacology of human GABAA receptors containing gamma 3 subunits.". Eur. J. Pharmacol. 291 (3): 301–309. 1996. doi:10.1016/0922-4106(95)90070-5. PMID 8719414. 
• "Identification and cloning of a gamma 3 subunit splice variant of the human GABA(A) receptor.". Brain Res. Mol. Brain Res. 78 (1–2): 201–203. 2000. doi:10.1016/S0169-328X(00)00085-1. PMID 10891602. 
• "Creation of genome-wide protein expression libraries using random activation of gene expression.". Nat. Biotechnol. 19 (5): 440–445. 2001. doi:10.1038/88107. PMID 11329013. 
• "Subunit specificity and interaction domain between GABA(A) receptor-associated protein (GABARAP) and GABA(A) receptors.". J. Neurochem. 80 (5): 815–823. 2002. doi:10.1046/j.0022-3042.2002.00762.x. PMID 11948245. 
• "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M. 
• "Association of GABRG3 with alcohol dependence.". Alcohol. Clin. Exp. Res. 28 (1): 4–9. 2004. doi:10.1097/01.ALC.0000108645.54345.98. PMID 14745296. 
• "Characterization of breakpoints in the GABRG3 and TSPY genes in a family with a t(Y;15)(p11.2;q12).". Am. J. Med. Genet. A 125 (2): 177–180. 2004. doi:10.1002/ajmg.a.20482. PMID 14981720. 

External links

• GABRG3+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.