Biology:HTR3A
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
5-hydroxytryptamine receptor 3A is a protein that in humans is encoded by the HTR3A gene.[1][2]
The product of this gene belongs to the ligand-gated ion channel receptor superfamily. This gene encodes subunit A of the type 3 receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor causes fast, depolarizing responses in neurons after activation. The A subunit is the only one that can be expressed alone and forms homomers with a very low single channel conductance of 0.6pS. When combined with the B subunit and expressed as a heteromer, the single channel conductance increases immensely. Alternatively spliced transcript variants encoding different isoforms have been identified.[3]
See also
References
- ↑ "Assignment of a human homolog of the mouse Htr3 receptor gene to chromosome 11q23.1-q23.2". Genomics 29 (1): 304–305. Feb 1996. doi:10.1006/geno.1995.1254. PMID 8530095.
- ↑ "A cytoplasmic region determines single-channel conductance in 5-HT3 receptors". Nature 424 (6946): 321–324. Jul 2003. doi:10.1038/nature01788. PMID 12867984. Bibcode: 2003Natur.424..321K. https://kar.kent.ac.uk/11375/1/KELLEY2003.doc.
- ↑ "Entrez Gene: HTR3A 5-hydroxytryptamine (serotonin) receptor 3A". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3359.
Further reading
- "Molecular cloning of human 5-hydroxytryptamine3 receptor: heterogeneity in distribution and function among species.". Mol. Pharmacol. 48 (3): 407–416. 1995. PMID 7565620.
- "Organisation of the murine 5-HT3 receptor gene and assignment to human chromosome 11.". FEBS Lett. 339 (3): 302–306. 1994. doi:10.1016/0014-5793(94)80435-4. PMID 8112471.
- "Cloning and functional expression of a human 5-hydroxytryptamine type 3AS receptor subunit.". Mol. Pharmacol. 48 (6): 1054–1062. 1996. PMID 8848005.
- "Molecular cloning of alternatively spliced human 5-HT3 receptor cDNAs.". Ann. N. Y. Acad. Sci. 861: 234–235. 1999. doi:10.1111/j.1749-6632.1998.tb10196.x. PMID 9928262.
- "The 5-HT3B subunit is a major determinant of serotonin-receptor function.". Nature 397 (6717): 359–363. 1999. doi:10.1038/16941. PMID 9950429. Bibcode: 1999Natur.397..359D.
- "Exon-intron organization of the human 5-HT3A receptor gene.". Neuropharmacology 39 (2): 308–315. 2000. doi:10.1016/S0028-3908(99)00116-1. PMID 10670426.
- "Distribution of [3H]GR65630 binding in human brain postmortem.". Neurochem. Res. 26 (3): 187–190. 2002. doi:10.1023/A:1010939530412. PMID 11495540.
- "Immunological characterization of 5-HT3 receptor transmembrane topology.". J. Mol. Neurosci. 18 (3): 169–178. 2003. doi:10.1385/JMN:18:3:169. PMID 12059035.
- "Assembly and cell surface expression of homomeric and heteromeric 5-HT3 receptors: the role of oligomerization and chaperone proteins.". Mol. Cell. Neurosci. 21 (1): 38–50. 2002. doi:10.1006/mcne.2002.1160. PMID 12359150.
- "Cloned human and murine serotonin(3A) receptors expressed in human embryonic kidney 293 cells display different single-channel kinetics.". Neurosci. Lett. 335 (1): 44–48. 2003. doi:10.1016/S0304-3940(02)01156-4. PMID 12457738.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Monitoring expression and clustering of the ionotropic 5HT3 receptor in plasma membranes of live biological cells". Biochemistry 42 (4): 877–884. 2003. doi:10.1021/bi026576d. PMID 12549905.
- "Effects of ginsenoside Rg2 on the 5-HT3A receptor-mediated ion current in Xenopus oocytes". Mol. Cells 15 (1): 108–113. 2003. PMID 12661769.
- "Cell surface expression of 5-hydroxytryptamine type 3 receptors is controlled by an endoplasmic reticulum retention signal". J. Biol. Chem. 278 (30): 27681–27687. 2003. doi:10.1074/jbc.M304938200. PMID 12750374.
- "Modulation of 5-HT3 receptor-mediated response and trafficking by activation of protein kinase C". J. Biol. Chem. 278 (36): 34150–34157. 2003. doi:10.1074/jbc.M303584200. PMID 12791692.
- "Binding interactions of antagonists with 5-hydroxytryptamine3A receptor models". J. Recept. Signal Transduct. Res. 23 (2–3): 255–270. 2004. doi:10.1081/RRS-120025568. PMID 14626451.
- "Investigation of the association between 5-HT3A receptor gene polymorphisms and efficiency of antiemetic treatment with 5-HT3 receptor antagonists". Pharmacogenetics 14 (5): 271–278. 2004. doi:10.1097/00008571-200405000-00001. PMID 15115912.
- "Minimal structural rearrangement of the cytoplasmic pore during activation of the 5-HT3A receptor". J. Biol. Chem. 279 (27): 28149–28158. 2004. doi:10.1074/jbc.M403545200. PMID 15131114.
External links
- HTR3A+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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