Biology:Gamma-aminobutyric acid receptor subunit alpha-1

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Short description: Protein-coding gene in humans


A representation of the 3D structure of the protein myoglobin showing turquoise α-helices.
Generic protein structure example

Gamma-aminobutyric acid receptor subunit alpha-1 is a protein that in humans is encoded by the GABRA1 gene.[1]

GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified.[2]

The GABRA1 receptor is the specific target of the z-drug class of nonbenzodiazepine hypnotic agents and is responsible for their hypnotic and hallucinogenic effects. The receptor also mediates the psychoactivity of muscimol, whose effects are qualitatively similar to those of Z-drugs.

See also

References

  1. ↑ "Confirmation of the localization of the human GABAA receptor alpha 1-subunit gene (GABRA1) to distal 5q by linkage analysis". Genomics 14 (3): 745–748. Dec 1992. doi:10.1016/S0888-7543(05)80178-8. PMID 1330891. 
  2. ↑ "Entrez Gene: GABRA1 gamma-aminobutyric acid (GABA) A receptor, alpha 1". https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=2554. 

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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See also
Receptor/signaling modulators
GABAA receptor positive modulators
GABA metabolism/transport modulators

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