Biology:CHRNA10
From HandWiki
Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Neuronal acetylcholine receptor subunit alpha-10, also known as nAChRα10 and cholinergic receptor nicotinic alpha 10, is a protein that in humans is encoded by the CHRNA10 gene.[1] The protein encoded by this gene is a subunit of certain nicotinic acetylcholine receptors (nAchR).
This nAchR subunit is required for the normal function of the olivocochlear system which is part of the auditory system.[2] Furthermore, selective block of α9α10 nicotinic acetylcholine receptors by the conotoxin RgIA has been shown to be analgesic in an animal model of nerve injury pain.[3]
α10 subunit-containing receptors are notably blocked by nicotine. The role of this antagonism in the effects of tobacco are unknown.
References
- ↑ "Molecular cloning and mapping of the human nicotinic acetylcholine receptor alpha10 (CHRNA10)". Genomics 73 (3): 272–83. May 2001. doi:10.1006/geno.2000.6503. PMID 11350119.
- ↑ "The alpha10 nicotinic acetylcholine receptor subunit is required for normal synaptic function and integrity of the olivocochlear system". Proc. Natl. Acad. Sci. U.S.A. 104 (51): 20594–9. December 2007. doi:10.1073/pnas.0708545105. PMID 18077337.
- ↑ "Molecular mechanism for analgesia involving specific antagonism of alpha9alpha10 nicotinic acetylcholine receptors". Proc. Natl. Acad. Sci. U.S.A. 103 (47): 17880–4. November 2006. doi:10.1073/pnas.0608715103. PMID 17101979. Bibcode: 2006PNAS..10317880V.
External links
- CHRNA10+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
- Human CHRNA10 genome location and CHRNA10 gene details page in the UCSC Genome Browser.
 |  |
