Biology:GABRP
From HandWiki
Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Gamma-aminobutyric acid receptor subunit pi is a protein that in humans is encoded by the GABRP gene.[1][2]
The gamma-aminobutyric acid (GABA) A receptor is a multisubunit chloride channel that mediates the fastest inhibitory synaptic transmission in the central nervous system. The subunit encoded by this gene is expressed in several non-neuronal tissues including the uterus and ovaries. This subunit can assemble with known GABA A receptor subunits, and the presence of this subunit alters the sensitivity of recombinant receptors to modulatory agents such as pregnanolone.[2]
See also
References
- ↑ "A novel class of GABAA receptor subunit in tissues of the reproductive system". J Biol Chem 272 (24): 15346–15350. Jul 1997. doi:10.1074/jbc.272.24.15346. PMID 9182563.
- ↑ 2.0 2.1 "Entrez Gene: GABRP gamma-aminobutyric acid (GABA) A receptor, pi". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2568.
Further reading
- "An update on GABAA receptors.". Brain Res. Brain Res. Rev. 29 (2–3): 196–217. 1999. doi:10.1016/S0165-0173(98)00052-6. PMID 10209232.
- "Systematic characterisation of GABRP expression in sporadic breast cancer and normal breast tissue". Int. J. Cancer 118 (6): 1453–1459. 2007. doi:10.1002/ijc.21517. PMID 16187283.
- "Genetic investigation of chromosome 5q GABAA receptor subunit genes in schizophrenia". Mol. Psychiatry 10 (12): 1074–1088, 1057. 2006. doi:10.1038/sj.mp.4001739. PMID 16172613.
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. 2004. doi:10.1038/ng1285. PMID 14702039.
- "Differential transcriptional regulation by human immunodeficiency virus type 1 and gp120 in human astrocytes". J. Neurovirol. 9 (3): 358–371. 2003. doi:10.1080/13550280390201119. PMID 12775419.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Incorporation of the pi subunit into functional gamma-aminobutyric Acid(A) receptors". Mol. Pharmacol. 56 (3): 598–610. 1999. doi:10.1124/mol.56.3.598. PMID 10462548.
- "Identification of amino acid residues within GABA(A) receptor beta subunits that mediate both homomeric and heteromeric receptor expression". J. Neurosci. 19 (15): 6360–6371. 1999. doi:10.1523/jneurosci.19-15-06360.1999. PMID 10414965.
External links
- GABRP+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
 |  |
