Biology:Glycosylceramidase
From HandWiki
| Glycosylceramidase | |||||||||
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| Identifiers | |||||||||
| EC number | 3.2.1.62 | ||||||||
| CAS number | 9033-10-7 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
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The enzyme glycosylceramidase (EC 3.2.1.62) catalyzes the following chemical reaction:
- glycosyl-N-acylsphingosine + H2O [math]\displaystyle{ \rightleftharpoons }[/math] N-acylsphingosine + a sugar
It belongs to the family of hydrolases, specifically those glycosidases that hydrolyse O- and S-glycosyl compounds. The systematic name of this enzyme class is glycosyl-N-acylsphingosine glycohydrolase. Other names in common use include phlorizin hydrolase, phloretin-glucosidase, glycosyl ceramide glycosylhydrolase, cerebrosidase, phloridzin β-glucosidase, lactase-phlorizin hydrolase, and phloridzin glucosidase.
References
- "On the identity between the small intestinal enzymes phlorizin hydrolase and glycosylceramidase". J. Biol. Chem. 248 (23): 8170–3. 1973. PMID 4752949.
- "A second enzyme defect in acquired lactase deficiency: lack of small-intestinal phlorizin-hydrolase". Eur. J. Clin. Invest. 2 (5): 326–31. 1972. doi:10.1111/j.1365-2362.1972.tb00658.x. PMID 5082068.
- "Phlorizin hydrolase: a β-glucosidase of hamster intestinal brush border membrane". Biochim. Biophys. Acta 173 (2): 245–56. 1969. doi:10.1016/0005-2736(69)90108-4. PMID 5774775.
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