Biology:Inosine nucleosidase
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Short description: Class of enzymes
| inosine nucleosidase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC number | 3.2.2.2 | ||||||||
| CAS number | 9030-95-9 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
In enzymology, an inosine nucleosidase (EC 3.2.2.2) is an enzyme that catalyzes the chemical reaction
- inosine + H2O [math]\displaystyle{ \rightleftharpoons }[/math] D-ribose + hypoxanthine
Thus, the two substrates of this enzyme are inosine and H2O, whereas its two products are D-ribose and hypoxanthine.
This enzyme belongs to the family of hydrolases, specifically those glycosylases that hydrolyse N-glycosyl compounds. The systematic name of this enzyme class is inosine ribohydrolase. Other names in common use include inosinase, and inosine-guanosine nucleosidase. This enzyme participates in purine metabolism.
References
- "Some enzymes of nucleoside metabolism of Escherichia coli". The Journal of Biological Chemistry 223 (1): 535–49. November 1956. PMID 13376622.
- "Fish muscle riboside hydrolases". The Biochemical Journal 59 (3): 386–91. March 1955. PMID 14363106.
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